Document Detail

Abnormal control of ventilation in adolescents with myelodysplasia.
MedLine Citation:
PMID:  2585225     Owner:  NLM     Status:  MEDLINE    
Infants with myelomeningocele have abnormalities in ventilatory control. To determine whether these persist into later life, we studied 14 patients with myelomeningocele and Arnold-Chiari malformation (age 18.0 +/- 0.8 (SE) years), and compared them with 14 control subjects (age 24.0 +/- 0.9 years). Pulmonary function and ventilatory muscle strength did not differ between patients with myelomeningocele and control subjects. Hypercapnic ventilatory responses were significantly lower in the group with myelomeningocele (1.98 L/min/mm Hg) compared with control values (3.33 L/min/mm Hg; p less than 0.01). Hypoxic ventilatory responses (-1.4 L/min/%oxygen saturation of hemoglobin in arterial blood) were not significantly different from control values (-2.14 L/min/%oxygen saturation). In control subjects the hypercapnic and hypoxic ventilatory responses were highly correlated with each other within subjects (r = 0.84; p less than 0.002) but not in those with myelomeningocele (r = 0.34; not significant). We concluded that adolescents and young adults with myelomeningocele have abnormalities in control of ventilation during sleep and wakefulness. We speculate that the Arnold-Chiari malformation interferes with central chemosensitivity (hypercapnic ventilatory response) and central integration of chemoreceptor output.
S Swaminathan; J Y Paton; S L Ward; R A Jacobs; C W Sargent; T G Keens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  115     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1990-01-02     Completed Date:  1990-01-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  898-903     Citation Subset:  AIM; IM    
Division of Neonatology and Pediatric Pulmonology, Childrens Hospital of Los Angeles, CA 90027.
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MeSH Terms
Anoxia / etiology*
Arnold-Chiari Malformation / complications*
Hypercapnia / etiology*
Neural Tube Defects / complications*
Respiratory Function Tests

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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