Document Detail

Abnormal coagulation results in patients with Hodgkin's disease.
MedLine Citation:
PMID:  3160235     Owner:  NLM     Status:  MEDLINE    
Case records of 177 patients admitted with Hodgkin's disease were reviewed to assess the frequency and significance of coagulation abnormalities. Prolongation of the prothrombin time, activated partial thromboplastin time, or thrombin time occurred in 56 patients, 32 percent of all evaluable cases. The most frequent clotting abnormalities involved the prothrombin time, which was increased in 43 patients (24 percent). Prothrombin time prolongation correlated with bulky or advanced disease as defined by stage (p = 0.001), constitutional symptoms (p less than 0.0001), massive mediastinal involvement (p = 0.02), and elevated alkaline phosphatase levels (p less than 0.0001). Abnormal coagulation test results followed the course of disease, normalizing with tumor regression and reappearing during relapse. Despite the surprising incidence of abnormal coagulation results, bleeding complications were reported in only two cases. Patients undergoing invasive procedures in the presence of clotting abnormalities fared no worse than those in whom procedures were cancelled. There is no evidence that complete staging evaluation should be comprised because of these abnormal test values. Extensive hematologic testing revealed no single mechanism to explain the coagulation factor disorders found in Hodgkin's disease.
E J Seifter; R I Parker; H R Gralnick; M Wesley; V T DeVita; R C Young; D L Longo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of medicine     Volume:  78     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-08-02     Completed Date:  1985-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  942-50     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Coagulation Disorders / etiology*
Fibrinogen / metabolism
Hodgkin Disease / complications*
Liver / pathology
Partial Thromboplastin Time
Platelet Count
Prothrombin Time
Thrombin Time
Thrombocytosis / etiology
Vitamin K Deficiency / etiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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