| Abnormal clearance of exogenous acid and increased acid sensitivity of the proximal duodenum in dyspeptic patients. | |
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MedLine Citation:
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PMID: 10029608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND & AIMS: Although acid is likely to play a role in the genesis of symptoms in dyspeptic patients, most studies have failed to show an increase in gastric acid secretion. The aim of this study was to investigate clearance of acid from the duodenum and its relationship with symptoms in patients with functional dyspepsia. METHODS: Twelve patients and 10 healthy volunteers were studied using an assembly allowing recording of pressures and pH. Acid and saline were infused intraduodenally during phase II and postprandially. Sensations were scored before and 1 and 5 minutes after each infusion. RESULTS: After acid infusion in the fasting period, a greater increase in acidity in the duodenal bulb (P = 0.007) and fewer duodenal pressure waves (P = 0.002) were observed in dyspeptic patients. No significant differences in the time with pH < 4 and duodenal motor activity were observed in the postprandial period. Acid infusion reproducibly increased the sensation of nausea in patients (P < 0.001) but not in the controls. Saline infusion had no effect on upper gastrointestinal sensations. CONCLUSIONS: In fasting dyspeptic patients, clearance of exogenous acid from the duodenal bulb and duodenal motor activity are decreased. The duodenal bulb in dyspeptic patients is hypersensitive to acid infusion, which induces the nausea. |
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Authors:
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M Samsom; M A Verhagen; G P vanBerge Henegouwen; A J Smout |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Gastroenterology Volume: 116 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-03-22 Completed Date: 1999-03-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 515-20 Citation Subset: AIM; IM |
Affiliation:
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Gastrointestinal Motility Unit, University Hospital Utrecht, Utrecht, The Netherlands. Samson.M@inter.NL.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Duodenum / drug effects, physiology, physiopathology* Dyspepsia / physiopathology* Female Gastrointestinal Motility / drug effects, physiology* Humans Hydrochloric Acid / administration & dosage, pharmacology* Hydrogen-Ion Concentration Infusions, Parenteral Intestinal Mucosa / drug effects, physiology, physiopathology* Male Postprandial Period Pressure Reference Values Sodium Chloride / administration & dosage, pharmacology |
| Chemical | |
Reg. No./Substance:
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7647-01-0/Hydrochloric Acid; 7647-14-5/Sodium Chloride |
| Comments/Corrections | |
Comment In:
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Gastroenterology. 1999 Mar;116(3):761-2
[PMID:
10029633
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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