| Abnormal circulatory stress responses of preterm graduates. | |
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MedLine Citation:
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PMID: 17314692 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Preterm birth and chronic lung disease may increase the risk of hypertension and cardiovascular disease in infancy and adolescence. Here we looked for evidence of early circulatory dysfunction associated with these perinatal complications. We compared infants born at term (n = 12) with those born preterm with an uncomplicated neonatal course (n = 12) or diagnosed with bronchopulmonary dysplasia (BPD) (n = 10). We measured blood pressure (BP) (Finometer), and heart rate (HR) responses to 4 min of breathing 4% CO2 during quiet sleep. Hypercapnia accelerated HR and increased BP of term infants. Preterm infants either (i) had an exaggerated pressor but little or no HR response to CO2 (healthy or mild-moderate BPD) or (ii) had a diminished pressor response and accompanying decrease in HR (severe BPD). Short-term reflex cardiovascular control was consequently altered by premature birth, with potentially more serious aberrations associated with severe BPD. Most anomalies had not resolved by the time infants born preterm reached term age; some may be early signs of emerging long-term cardiovascular dysfunction. |
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Authors:
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Gary Cohen; Hugo Lagercrantz; Miriam Katz-Salamon |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatric research Volume: 61 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-22 Completed Date: 2007-04-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 329-34 Citation Subset: IM |
Affiliation:
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Department of Women and Child Health, Neonatal Unit, Karolinska Institute, S-171 76 Stockholm, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Blood Pressure Bronchopulmonary Dysplasia / complications, physiopathology Cardiovascular System / physiopathology* Female Heart Rate Humans Hypercapnia / physiopathology Infant Infant, Newborn Infant, Premature Male Stress, Physiological / complications, physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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