Document Detail


Abnormal chromatin clumping in granulocytes in a case of Ph1-negative, BCR-ABL rearrangement positive, haematologically atypical chronic myeloid leukaemia (CML).
MedLine Citation:
PMID:  8904205     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, we report the case of a patient displaying an abnormal chromatin clumping (ACC) syndrome, a rare disease which shares features with both myeloproliferative and myelodysplastic disorders. Although various non specific cytogenetic abnormalities have been observed in ACC, the presence of a Ph1 chromosome has not been reported. In our patient, despite a lack of Ph1, PCR analysis of blood and bone marrow samples revealed a BCR-ABL rearrangement. These results indicate that at least some cases of ACC syndrome could represent a form of Ph1-negative chronic myeloid leukaemia.
Authors:
G Tertian; M Misrahi; D Diallo; F Mielot; C Leonard; S Salmeron; G Tchernia
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Nouvelle revue française d'hématologie     Volume:  37     ISSN:  -     ISO Abbreviation:  Nouv Rev Fr Hematol     Publication Date:  1995  
Date Detail:
Created Date:  1997-02-19     Completed Date:  1997-02-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7909092     Medline TA:  Nouv Rev Fr Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  245-7     Citation Subset:  IM    
Affiliation:
Laboratoire d'Hematologie, Centre Hospitalier et Universitaire de Bicetre, Le Kremlin-Bicetre, France.
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MeSH Terms
Descriptor/Qualifier:
Aged
Base Sequence
Bone Marrow Examination
Chromatin / ultrastructure*
Fusion Proteins, bcr-abl / genetics*
Gene Rearrangement*
Granulocytes / ultrastructure*
Humans
Karyotyping
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / blood,  genetics*,  pathology
Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / blood,  genetics*,  pathology
Male
Molecular Sequence Data
Polymerase Chain Reaction
Syndrome
Translocation, Genetic
Chemical
Reg. No./Substance:
0/Chromatin; 0/Fusion Proteins, bcr-abl

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