Document Detail

Abnormal chloride and potassium conductances in cultured embryonic tongue muscle from trisomy 16 mouse.
MedLine Citation:
PMID:  10960688     Owner:  NLM     Status:  MEDLINE    
Trisomy 16 (Ts16) mouse is considered an animal model of Down syndrome (human trisomy 21). Whole-cell patch-clamp was used to evaluate potassium and chloride currents of cultured tongue muscle cells from fetal Ts16 and diploid mice. No difference was found in membrane capacitance between the two groups. K(+) and Cl(-) currents were pharmacologically isolated. K(+) conductance was reduced by 31% in Ts16 cells (373 pS/pF) compared with diploid cells (539 pS/pF). Cl(-) conductance was 51% larger in Ts16 cells (103 pS/pF) compared with diploid cells (68 pS/pF). However kinetics for K(+) and Cl(-) currents did not differ between the cell types. An increase in Cl(-) conductance and a decrease in K(+) conductance in Ts16 muscle cells, if present in muscle of Down syndrome subjects, might account for the observed hypotonia in these subjects.
S Peng; S I Rapoport; R J Pearce; Z Galdzicki
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Brain research. Developmental brain research     Volume:  122     ISSN:  0165-3806     ISO Abbreviation:  Brain Res. Dev. Brain Res.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-10-30     Completed Date:  2000-11-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8908639     Medline TA:  Brain Res Dev Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  193-7     Citation Subset:  IM    
Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Room 6C-103, Building 10, 9000 Rockville Pike, Bethesda, Maryland, MD 20892, USA.
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MeSH Terms
Chlorides / physiology*
Culture Techniques
Disease Models, Animal
Down Syndrome / genetics
Electric Conductivity
Embryo, Mammalian / physiology
Mice / genetics
Mice, Inbred C57BL
Muscles / embryology,  pathology
Potassium / physiology*
Tongue / embryology*,  pathology
Trisomy / pathology,  physiopathology*
Reg. No./Substance:
0/Chlorides; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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