Document Detail


Abnormal cerebral blood volume in regions of contused and normal appearing brain following traumatic brain injury using perfusion magnetic resonance imaging.
MedLine Citation:
PMID:  11437081     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Following traumatic brain injury, there may be secondary alterations in cerebrovascular parameters leading to ischemia and further cellular damage. To assess possible subacute hemodynamic disturbances following traumatic brain injury, we used conventional and perfusion magnetic resonance imaging (MRI) in 18 patients, on average 10 days following injury. Six of the 18 patients had focal contusions or edema visible on conventional MRI. These six patients had a significantly reduced normalized regional cerebral blood volume (rCBV) in the regions of focal pathology compared to equivalent areas in control subjects (patients 0.47 +/- 0.20 [means +/- SD], controls 1.02 +/- 0.11, p < 0.001). In addition, four of these six patients had an increased rCBV (outside control range) in the region of normal appearing brain immediately surrounding the contusion. These six patients were more significantly injured and had a worse clinical outcome compared to the remaining patients (p = 0.004,p = 0.03, respectively). There were five patients who had a region of reduced rCBV (outside control range) in a quadrant of normal appearing white matter, away from any visible abnormality, who were not more significantly injured than the remaining patients but went on to have a significantly poorer clinical outcome (p = 0.27, p = 0.01, respectively). Traumatic brain injury is a heterogeneous insult causing a variety of pathology, not all of which is visible using conventional imaging methods. The current study has shown that regions of both normal appearing and contused brain may have an abnormal rCBV and that alterations in rCBV may play a role in determining the clinical outcome of patients.
Authors:
M R Garnett; A M Blamire; R G Corkill; B Rajagopalan; J D Young; T A Cadoux-Hudson; P Styles
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurotrauma     Volume:  18     ISSN:  0897-7151     ISO Abbreviation:  J. Neurotrauma     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-04     Completed Date:  2001-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8811626     Medline TA:  J Neurotrauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  585-93     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Oxford, United Kingdom. mg@bioch.ox.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Volume / physiology*
Brain Injuries / pathology*
Cerebrovascular Circulation / physiology*
Contusions / pathology*
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Middle Aged
Perfusion
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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