Document Detail


Abnormal cardiovascular and catecholamine responses to supine exercise in human subjects with sympathetic dysfunction.
MedLine Citation:
PMID:  7602525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. The cardiovascular and catecholamine responses to supine leg exercise were measured in fifteen normal subjects (controls) and in three groups with sympathetic dysfunction: fifteen with central failure (Shy-Drager syndrome; SDS), fifteen with peripheral failure (pure autonomic failure; PAF) and two with isolated dopamine beta-hydroxylase deficiency (DBH deficiency). 2. With exercise, blood pressure increased in controls, fell markedly in SDS and PAF and was unchanged in DBH deficiency. After exercise, blood pressure rapidly returned to baseline in controls, but remained low in SDS and PAF. With exercise, heart rate increased more in controls than SDS or PAF; the response varied in DBH deficiency. 3. With exercise, cardiac output increased similarly in controls, SDS and PAF, with a larger increase in DBH deficiency. Vascular resistance fell less in controls than SDS, PAF and DBH deficiency. 4. With exercise, plasma noradrenaline increased in controls only; plasma adrenaline remained unchanged in all groups. In DBH deficiency, plasma noradrenaline and adrenaline were undetectable, but plasma dopamine was elevated and rose further with exercise. 5. Supine exercise substantially lowered blood pressure in sympathetic failure due to SDS and PAF. In DBH deficiency blood pressure was unchanged; this lack of fall may have been due to vasoconstriction induced by dopamine and other substances released from otherwise intact sympathetic terminals, or to preserved cardiac vagal function.
Authors:
G D Smith; L P Watson; D V Pavitt; C J Mathias
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of physiology     Volume:  484 ( Pt 1)     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  1995 Apr 
Date Detail:
Created Date:  1995-08-10     Completed Date:  1995-08-10     Revised Date:  2010-08-25    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  255-65     Citation Subset:  IM; S    
Affiliation:
Department of Medicine, St Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Autonomic Nervous System Diseases / physiopathology*
Blood Pressure / physiology
Catecholamines / blood,  metabolism*
Dopamine / blood
Dopamine beta-Hydroxylase / deficiency
Exercise / physiology*
Female
Heart Rate / physiology
Humans
Hypotension
Leg / physiology
Male
Middle Aged
Posture
Shy-Drager Syndrome / physiopathology
Supine Position / physiology*
Sympathetic Nervous System / physiopathology*
Temperature
Time Factors
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
0/Catecholamines; EC 1.14.17.1/Dopamine beta-Hydroxylase
Comments/Corrections

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