Document Detail

Abnormal cardiocoronary thromboxane A2 production in patients with unstable angina.
MedLine Citation:
PMID:  3984828     Owner:  NLM     Status:  MEDLINE    
Thromboxane B2 (TXB2), the stable metabolite of thromboxane A2 (TXA2), was measured in the coronary sinus and in aortic blood before and after cold pressor test (CPT) in 21 patients suffering from ischemic heart disease (7 affected by stable effort angina and 14 by unstable angina) and in 12 patients not suffering from myocardial ischemia (control group) during coronary angiography. Aspirin (10 mg/kg intravenously) was administered before catheterization in order to prevent platelet and leukocyte TXA2 formation. Control subjects and patients with effort angina had TXB2 resting levels lower than unstable angina patients without a transcardiac gradient which, on the contrary, was found in unstable angina patients. Only in these patients CPT resulted in a significant TXB2 increase more marked in the coronary sinus (from 50.0 +/- 18.9 pg/ml to 73.0 +/- 35.1 pg/ml, p less than 0.001) than in the aorta (from 33.4 +/- 17.1 pg/ml to 42.6 +/- 24.0 pg/ml, p less than 0.05), so that the transcardiac TXB2 gradient significantly increased. In all but two unstable angina patients, TXB2 elevation was not associated with a fall of cardiac lactate extraction. The resting and CPT-induced TXB2 gradients were unrelated to the presence and severity of coronary angiographic lesions. These results indicate that unstable angina patients show an abnormal cardiocoronary capacity to synthesize TXA2, which seems not to be elicited by the occurrence of myocardial ischemia.
G G Neri Serneri; G F Gensini; R Abbate; D Prisco; P G Rogasi; R Laureano; G C Casolo; F Fantini; M Di Donato; R P Dabizzi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American heart journal     Volume:  109     ISSN:  0002-8703     ISO Abbreviation:  Am. Heart J.     Publication Date:  1985 Apr 
Date Detail:
Created Date:  1985-05-01     Completed Date:  1985-05-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  732-8     Citation Subset:  AIM; IM    
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MeSH Terms
Angina Pectoris / blood*
Angina, Unstable / blood*,  physiopathology
Cold Temperature / diagnostic use
Coronary Angiography
Coronary Vessels / metabolism
Lactates / blood
Middle Aged
Sympathetic Nervous System / physiopathology
Thromboxane A2 / biosynthesis*,  blood
Thromboxane B2 / biosynthesis,  blood
Thromboxanes / biosynthesis*
Reg. No./Substance:
0/Lactates; 0/Thromboxanes; 54397-85-2/Thromboxane B2; 57576-52-0/Thromboxane A2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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