Document Detail


Abnormal cardiac autonomic control in sickle cell disease following transient hypoxia.
MedLine Citation:
PMID:  19163084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Abnormalities in autonomic control in sickle cell anemia (SCA) patients have been reported by multiple researchers. However their potential causal association with sickle cell crisis remains unknown. We employed hypoxia, a known trigger to sickle cell crisis, to perturb the autonomic systems of the subjects. Cardiac autonomic control was non-invasively assessed by tracking the changes in heart rate variability (HRV) that occur following brief exposure to a hypoxia stimulus. Time varying spectral analysis of HRV was applied to estimate the cardiac autonomic response to the transient episode of hypoxia. The results demonstrate that cardiovascular autonomic response to hypoxia is substantially more sensitive in SCA than in normal controls. We also developed a model to compensate for the confounding effects of respiration on the HRV spectral indices by using the corresponding respiration signal to compensate for the respiratory correlated part of the HRV. This technique improved the resolution with which the effect of hypoxia on changes in HRV could be measured.
Authors:
Suvimol Sangkatumvong; Michael C K Khoo; Thomas D Coates
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference     Volume:  2008     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2008  
Date Detail:
Created Date:  2009-02-16     Completed Date:  2009-05-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1996-9     Citation Subset:  IM    
Affiliation:
Biomedical Engineering Department, University of Southern California, Los Angeles, CA 90089, USA. sangkatu@usc.edu
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Anemia, Sickle Cell / physiopathology*
Anoxia / physiopathology
Autonomic Nervous System / physiopathology*
Biomedical Engineering
Case-Control Studies
Child
Heart / physiopathology*
Heart Rate / physiology
Humans
Models, Cardiovascular
Respiration
Grant Support
ID/Acronym/Agency:
EB-001978/EB/NIBIB NIH HHS; R01-HL07180/HL/NHLBI NIH HHS; RR00047/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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