Document Detail


Abnormal atrial repolarization and depolarization contribute to the inducibility of atrial fibrillation in Brugada syndrome.
MedLine Citation:
PMID:  20558904     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Brugada syndrome is often accompanied by atrial tachyarrhythmia, such as atrial fibrillation (AF). The aim of this study was to examine atrial vulnerability in patients with Brugada syndrome. Two groups of patients were compared: 18 patients with Brugada syndrome (Brugada syndrome group) and 11 age-matched patients with neither organic heart disease nor AF episodes (control group). Programmed electrical stimulation was performed from the right atrium (RA), and the effective refractory period of the right atrium (ERP-RA), interatrial conduction time (IACT), monophasic action potentials (MAPs) at the high RA, and the inducibility of AF lasting > 30 seconds were studied. MAP duration at 80% repolarization (MAPD(80)) was calculated. AF was induced with a single extrastimulus or double extrastimuli in all patients with Brugada syndrome but in none of the control patients. The ERP-RA did not differ between the groups. IACT at the shortest diastolic interval was significantly increased in the Brugada syndrome group compared to that in the control group. The maximum slope of the MAPD(80) restitution curve was significantly steeper in the Brugada syndrome group than in the control group (2.4 + or - 2.0 versus 0.82 + or - 0.36, P < 0.02). Ventricular fibrillation was induced with ventricular programmed stimulation in all Brugada syndrome patients. Both abnormal interatrial conduction and steep restitution of action potential duration may contribute to the atrial arrhythmogenicity in Brugada syndrome.
Authors:
Masayoshi Kofune; Ichiro Watanabe; Kimie Ohkubo; Sonoko Ashino; Yasuo Okumura; Koichi Nagashima; Toshiko Nakai; Yuji Kasamaki; Atsushi Hirayama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International heart journal     Volume:  51     ISSN:  1349-2365     ISO Abbreviation:  Int Heart J     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-06-18     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101244240     Medline TA:  Int Heart J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  159-65     Citation Subset:  IM    
Affiliation:
Division of Cardiology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Action Potentials / physiology
Adult
Aged
Atrial Fibrillation / diagnosis,  etiology*,  physiopathology*
Brugada Syndrome / complications*,  physiopathology*,  therapy
Case-Control Studies
Catheter Ablation
Cohort Studies
Defibrillators, Implantable
Electric Stimulation
Female
Heart Atria / physiopathology
Heart Conduction System / physiopathology
Humans
Male
Middle Aged
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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