| Abnormal achromatic and chromatic contrast sensitivity in Neurofibromatosis type 1. | |
| | |
MedLine Citation:
|
PMID: 22190595 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Purpose.Neurofibromatosis type 1 (NF1) is a monogenic disorder with the majority of patients presenting subtle to moderate cognitive impairments. Visuospatial deficits are considered to be one of the hallmark characteristics of their cognitive profile. However, low-level visual processing has not been previously investigated. Our aim was to study contrast perception in these patients in order to assess the function of early visual areas.Methods.We tested the contrast sensitivity of 19 children and adolescents with NF1 and 33 control children and adolescents and 12 adults with NF1 and 24 control adults. The tasks used probed two achromatic spatiotemporal frequency channels and chromatic red-green and blue-yellow pathways.Results.Individuals with NF1 showed significant contrast sensitivity deficits for the achromatic higher spatial frequency channel [F((1, 83))=36.1, p<0.001] and for the achromatic low spatial high temporal (magnocellular) frequency channel [F((1,72))=8.0, p<0.01]. Furthermore, individuals with NF1 presented a significant deficit in chromatic red-green (parvocellular) contrast sensitivity (p<0.01) but not in blue-yellow (koniocelular) sensitivity. The decrease in achromatic sensitivity for higher spatial frequency was observed throughout the visual field, in both central and peripheral locations. In contrast, central contrast sensitivity for the magnocellular-biased condition was relatively preserved and only peripheral sensitivity was affected. Interestingly, we found the same pattern of deficits in both age groups tested.Conclusions.These findings showed that contrast sensitivity is impaired in patients with NF1, associating for the first time abnormal low-level vision to the cognitive profile of this disorder. |
| | |
Authors:
|
Maria José Ribeiro; Inês Ribeiro Violante; Inês Bernardino; Fabiana Ramos; Jorge Saraiva; Pablo Reviriego; Meena Upadhyaya; Eduardo Duarte Silva; Miguel Castelo-Branco |
Related Documents
:
|
17974325 - Structural influences on initial accent placement in french. 2921415 - Modeling the perception of concurrent vowels: vowels with the same fundamental frequency. 10573905 - Integrality of nasalization and f1. ii. basic sensitivity and phonetic labeling measure... 8865645 - Effects of phase and level on vowel identification: data and predictions based on a non... 12689475 - Noise: combating a ubiquitous and hazardous pollutant. 6766345 - Compensation for substrate elasticity in the kinematics of leaping by infant pigtailed ... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-21 |
Journal Detail:
|
Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Visual Neuroscience Laboratory, IBILI, Faculty of Medicine, University of Coimbra, Az. de Sta Comba, 3000-548 Coimbra, Portugal; Tel: +351 239480210; Fax: +351 239480280; |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: C9-R95X Polymorphism in Patients with Neovascular Age-Related Macular Degeneration.
Next Document: GNAT1 associated with Autosomal Recessive Congenital Stationary Night Blindness.