Document Detail


Abnormal T cell subpopulations and circulating immune complexes in the Guillain-Barré syndrome and multiple sclerosis.
MedLine Citation:
PMID:  306075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunologic studies were performed in 21 patients with multiple sclerosis (MS) and 16 with the Guillain-Barré syndrome (GBS). Levels of thymus-derived (T) cells measured by "total" and "active" rosette formation between sheep erythrocytes and peripheral blood mononuclear cells (TEt, TEa) were within normal limits in all the patients, with the exception of four GBS patients, including one who also had received chemotherapy for lymphoma and three who were receiving steroids. When lymphocytes from the 21 patients were incubated with the bone-marrow-derived (B) lymphoblastoid cell line PGLC-33H, there were, for 12 of 18 MS patients and 11 of 16 GBS patients, significant decreases in a subpopulation of peripheral blood T lymphocytes that form "PGLC rosettes" (PGR) with the PGLC-33H cells. (Peripheral blood T cells from normal individuals formed PGR with 23.9 +/- 3.8 percent of PGLC-33H cells.) Using the 125l-C1q binding assay, immune complexes were detected in the serum of 14 of 19 MS patients and 15 of 16 GBS patients. An association between increased C1q binding and decreased PGR values was found in 10 of 18 MS patients and 12 of 17 GBS patients. The results suggest that in both diseases the etiology may involve a decrease in the subset of T cells that bind to the IgM-producing cell line PGLC-33H, in association with the appearance of circulating immune complexes containing the infectious viral agent.
Authors:
J M Goust; F Chenais; J E Carnes; C G Hames; H H Fudenberg; E L Hogan
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurology     Volume:  28     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1978 May 
Date Detail:
Created Date:  1978-06-12     Completed Date:  1978-06-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  421-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antigen-Antibody Complex*
Humans
Leukocyte Count
Multiple Sclerosis / immunology*
Polyradiculopathy / immunology*
Rosette Formation
T-Lymphocytes / immunology*
Chemical
Reg. No./Substance:
0/Antigen-Antibody Complex

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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