Document Detail

Abnormal sympathetic reactivity to the cold pressor test in overweight humans.
MedLine Citation:
PMID:  22895452     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Overweight individuals (body mass index (BMI) 25-29.9 kg/m²) are at higher risk for developing cardiovascular disease and hypertension when compared with lean individuals of normal weight (BMI 18.5-24.9 kg/m²). The purpose of this study was to test the hypothesis that exaggerated sympathetic nervous system responses to stressors may be one potential mechanism that predisposes overweight individuals to developing hypertension.
METHODS: We compared heart rate (HR), blood pressure (BP), and muscle sympathetic nerve activity (MSNA) using microneurography, in normotensive overweight individuals compared with age-matched lean controls, at baseline and during two sympathoexcitatory maneuvers: cold pressor test (CPT), and static handgrip exercise (SHG 30%).
RESULTS: During CPT, MSNA increased in both groups, but the magnitude of MSNA response was significantly greater (P = 0.03) in overweight (+18.1 ± 2.8 bursts/min) compared with lean controls (+10.8 ± 1.2 bursts/min). MSNA response to SHG at 30% maximum voluntary contraction (MVC) was similar between the two groups. There were no significant differences in systolic (SBP) or diastolic BP (DBP) responses or HR responses between the two groups during either maneuver.
CONCLUSIONS: Normotensive overweight individuals have an exaggerated MSNA response to the CPT. Augmented sympathetic reactivity to cold stress may contribute to increased risk of hypertension in overweight individuals.
Jeanie Park; Holly R Middlekauff; Vito M Campese
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-16
Journal Detail:
Title:  American journal of hypertension     Volume:  25     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-05-14     Revised Date:  2013-12-05    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1236-41     Citation Subset:  IM    
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MeSH Terms
Blood Pressure*
Body Mass Index
Case-Control Studies
Cold-Shock Response*
Exercise Test
Hand Strength
Heart / innervation*
Heart Rate*
Hypertension / etiology,  physiopathology
Muscle, Skeletal / innervation*
Overweight / complications,  diagnosis,  physiopathology*
Predictive Value of Tests
Risk Factors
Sympathetic Nervous System / physiopathology*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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