Document Detail


Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophrenia.
MedLine Citation:
PMID:  20720534     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Psychosis has been associated with aberrant brain activity concurrent with both the anticipation and integration of monetary outcomes. The extent to which abnormal reward-related neural signals can be observed in chronic, medicated patients with schizophrenia (SZ), however, is not clear. In an fMRI study involving 17 chronic outpatients with SZ and 17 matched controls, we used a monetary incentive delay (MID) task, in which different-colored shapes predicted gains, losses, or neutral outcomes. Subjects needed to respond to a target within a time window in order to receive the indicated gain or avoid the indicated loss. Group differences in blood-oxygen-level-dependent responses to cues and outcomes were assessed through voxel-wise whole-brain analyses and regions-of-interest analyses in the neostriatum and prefrontal cortex (PFC). Significant group by outcome valence interactions were observed in the medial and lateral PFC, lateral temporal cortex, and amygdalae, such that controls, but not patients, showed greater activation for gains, relative to losses. In the striatum, neural activity was modulated by outcome magnitude in both groups. Additionally, we found that ratings of negative symptoms in patients correlated with sensitivity to obtained losses in medial PFC, obtained gains in lateral PFC, and anticipated gains in left ventral striatum. Sensitivity to obtained gains in lateral PFC also correlated with positive symptom scores in patients. Our findings of systematic relationships between clinical symptoms and neural responses to stimuli associated with rewards and punishments offer promise that reward-related neural responses may provide sensitive probes of the effectiveness of treatments for negative symptoms.
Authors:
James A Waltz; Julie B Schweitzer; Thomas J Ross; Pradeep K Kurup; Betty J Salmeron; Emma J Rose; James M Gold; Elliot A Stein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2010-08-18
Journal Detail:
Title:  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology     Volume:  35     ISSN:  1740-634X     ISO Abbreviation:  Neuropsychopharmacology     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-15     Completed Date:  2011-02-16     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  8904907     Medline TA:  Neuropsychopharmacology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2427-39     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Basal Ganglia / physiopathology*
Brain Mapping / methods
Cerebral Cortex / physiopathology*
Cues
Female
Humans
Magnetic Resonance Imaging / methods
Male
Reinforcement (Psychology)*
Schizophrenia / physiopathology*
Schizophrenic Psychology*
Self Report
Grant Support
ID/Acronym/Agency:
1 K12 RR023250-01/RR/NCRR NIH HHS; 1 R24 MH72647-01A1/MH/NIMH NIH HHS; K12 RR023250/RR/NCRR NIH HHS; K12 RR023250-01/RR/NCRR NIH HHS; P30 MH068580/MH/NIMH NIH HHS; P30 MH068580-01/MH/NIMH NIH HHS; P30 MH068580-01/MH/NIMH NIH HHS; R24 MH072647/MH/NIMH NIH HHS; R24 MH072647-01A1/MH/NIMH NIH HHS
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