Document Detail

Abnormal P600 word repetition effect in elderly persons with preclinical Alzheimer's disease.
MedLine Citation:
PMID:  24090465     Owner:  NLM     Status:  MEDLINE    
We sought cognitive event-related potential (ERP) biomarkers of "Preclinical Alzheimer's disease" (Pre-AD) using an incidental verbal learning paradigm with high sensitivity to prodromal AD. Seven elderly persons, with normal cognition at the time of ERP recordings, but who showed subsequent cognitive decline or AD pathology at autopsy (n = 5, mean Braak stage = 2.8), were compared to 12 "robust" normal elderly (RNE) persons who remained cognitively normal (Mfollow-up = 9.0 years). EEG was recorded during a word repetition paradigm (semantically congruous (50%) and incongruous target words repeat ~10-140 seconds later). The RNE P600 congruous word repetition ERP effects (New minus Old congruous words) were significantly larger than in Pre-AD (mean amplitudes = 3.28 vs. 0.10 μV, p = .04). High group discrimination (84%) was achieved (by a P600 amplitude cutoff of ~1.5 μV). Abnormal P600 word repetition effects in cognitively normal elderly persons may be an important sign of synaptic dysfunction and Preclinical AD.
John M Olichney; Jamie Pak; David P Salmon; Jin-Chen Yang; Tim Gahagan; Ralph Nowacki; Lawrence Hansen; Douglas Galasko; Marta Kutas; Vicente J Iragui-Madoz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-10-04
Journal Detail:
Title:  Cognitive neuroscience     Volume:  4     ISSN:  1758-8936     ISO Abbreviation:  Cogn Neurosci     Publication Date:  2013  
Date Detail:
Created Date:  2013-11-22     Completed Date:  2014-07-09     Revised Date:  2014-11-18    
Medline Journal Info:
Nlm Unique ID:  101518151     Medline TA:  Cogn Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  143-51     Citation Subset:  IM    
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MeSH Terms
Alzheimer Disease / diagnosis*,  physiopathology
Analysis of Variance
Cognition Disorders / diagnosis*,  physiopathology
Discrimination (Psychology) / physiology
Evoked Potentials / physiology
Repetition Priming / physiology
Retrospective Studies
Verbal Learning / physiology*
Grant Support
P30 AG010129/AG/NIA NIH HHS; P30 AG10129/AG/NIA NIH HHS; P50 AG005131/AG/NIA NIH HHS; P50 AG05131/AG/NIA NIH HHS; R01 AG008313/AG/NIA NIH HHS; R01 AG018442/AG/NIA NIH HHS; R01 AG08313/AG/NIA NIH HHS; R01 AG18442/AG/NIA NIH HHS; R01 HD022614/HD/NICHD NIH HHS

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