Document Detail

Abnormal Interhemispheric Connectivity in Neonates with D-Transposition of the Great Arteries Undergoing Cardiopulmonary Bypass Surgery.
MedLine Citation:
PMID:  23042920     Owner:  NLM     Status:  Publisher    
BACKGROUND AND PURPOSE:Neonates with severe CHD require CPB within the first days of life. White matter injury can occur before surgery, and this may impair the long-term neurodevelopmental and psychosocial outcome. The purpose of this study was to assess the microstructural development of the CC in infants with CHD before and after CPB for transposition of the great arteries.MATERIALS AND METHODS:Fifteen patients with CHD and 11 age-matched HC were recruited. We separately quantified the parallel (E(1)) and perpendicular (E(23)) diffusions, the ADC, and FA of the genu of the CC and splenium of the CC before and after surgery.RESULTS:In presurgical measures of the genu of the CC, higher E(23) (P = .018), higher ADC (P = .026), and lower FA (P = .033) values were measured compared with those in HC. In the postsurgery scans, the genu of the CC had higher E(23) (P = .013), higher ADC (P = .012), and lower FA (P = .033) values compared with those in HC. There was no significant difference in any DTI indices between the pre- and postsurgical groups.CONCLUSIONS:We report abnormal microstructural development in the genu of the CC of infants with d-TGA before and after CPB. High E(23), high ADC, and low FA values in the genu of the CC may be explained by abnormal axonal pruning, thinner myelin sheaths, smaller axonal diameters, or more oligodendrocytes. It appears that the genu of the CC is more vulnerable than the splenium of the CC in patients with CHD and may serve as a biomarker to identify infants at highest risk for adverse neurodevelopmental outcome.
M Makki; I Scheer; C Hagmann; R Liamlahi; W Knirsch; H Dave; V Bernet; K Batinic; B Latal
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-4
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  -     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Diagnostic Imaging, Division of Cardiology, Division of Congenital Cardiovascular Surgery, Pediatric Intensive Care and Neonatology, and Child Development Center, University Children's Hospital, Zurich, Switzerland; and Clinic of Neonatology, University Hospital of Zurich, Zurich, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Carotid Artery Plaque Characterization Using CT Multienergy Imaging.
Next Document:  Parotid Gland Atrophy in Patients with Chronic Trigeminal Nerve Denervation.