| Abnormal Glucose Tolerance: A Predictor Of 30-Day Mortality In Patients With Decompensated Liver Cirrhosis. | |
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MedLine Citation:
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PMID: 21391163 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: In liver cirrhosis an abnormal glucose tolerance correlates with a poor long-term prognosis. The aim of this study was to evaluate whether a disturbed glucose metabolism predicts the short-term prognosis in hospitalized patients with decompensated liver cirrhosis. METHODS: Seventy-eight patients with liver cirrhosis were prospectively enrolled. Disturbed glucose metabolism was determined by a 75-g oral glucose tolerance test (OGTT) according to WHO criteria. Differences in survival were assessed by χ (2) test for 30-day mortality and by multivariate Cox proportional hazards analysis for long-term survival. RESULTS: Impaired glucose tolerance (IGT) was diagnosed in 29 patients (37 %) and diabetes mellitus (DM) in 26 patients (33 %). A pathological OGTT result was a significant negative predictor of a poor 30-day survival compared to NGT (OR 8.6; p = 0.03). DM but not IGT was an independent negative predictor of long-term survival (HR = 1.89; p = 0.04). CONCLUSION: Disturbed glucose metabolism in hospitalized patients with decompensated liver cirrhosis is correlated with increased 30-day mortality. OGTT appears to be useful for identifying cirrhotic patients with poor short term prognosis. |
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Authors:
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S Hagel; T Bruns; A Herrmann; A Stallmach; C Schmidt |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-9 |
Journal Detail:
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Title: Zeitschrift fur Gastroenterologie Volume: 49 ISSN: 1439-7803 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0033370 Medline TA: Z Gastroenterol Country: - |
Other Details:
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Languages: ENG Pagination: 331-334 Citation Subset: - |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Division of Gastroenterology, Hepatology, and Infectious Diseases, Department of Internal Medicine II, Friedrich-Schiller-University, Jena, Germany. |
Vernacular Title:
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Pathologische Glukosetoleranz: ein Prädiktor für das Kurzzeit-Überleben bei Patienten mit dekompensierter Leberzirrhose. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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