Document Detail


Abnormal cerebellar structure is dependent on phenotype of isolated cleft of the lip and/or palate.
MedLine Citation:
PMID:  23055082     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Isolated cleft lip and/or palate (ICLP) is one of the most common congenital birth defects in the USA, affecting roughly 1 in 600 births annually. Along with the facial deformity, this population has been found to have abnormal neurodevelopment and gross structural abnormalities in the brain, particularly within the cerebellum. The current study examined cerebellar structure within the two primary subtypes of ICLP: cleft lip with/without cleft palate (CL/P) and cleft palate alone (CPO). A large sample of 107 subjects aged 7 to 27 years with ICLP was compared to 127 healthy controls. Samples were separated by sex. Brain structure was obtained via magnetic resonance imaging. For males, after controlling for intracranial volume, cerebellum volume was significantly lower in the ICLP group (F = 12.351, p = 0.001). Regionally in the cerebellum, males with ICLP had proportionally larger anterior lobes (F = 4.022, p = 0.047) and smaller superior posterior lobes (F = 5.686, p = 0.019). CL/P males showed only a reduction in overall cerebellum volume, with no regional changes. CPO males showed only regional changes, with no reduction in overall volume. Females with ICLP showed no overall or regional cerebellar abnormalities. However, females with CPO did have significantly lower cerebellum volumes than controls. The results reveal both global and regional cerebellar abnormalities within subjects with ICLP. They also establish the existence of abnormal cerebellar morphologies that are dependent on cleft subtype as well as sex. This lends further support to the claim that CL/P and CPO are distinct conditions.
Authors:
Ian DeVolder; Lynn Richman; Amy L Conrad; Vincent Magnotta; Peg Nopoulos
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cerebellum (London, England)     Volume:  12     ISSN:  1473-4230     ISO Abbreviation:  Cerebellum     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-05     Revised Date:  2014-04-02    
Medline Journal Info:
Nlm Unique ID:  101089443     Medline TA:  Cerebellum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  236-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Analysis of Variance
Cerebellum / abnormalities*,  pathology
Child
Cleft Lip / pathology*,  physiopathology*
Cleft Palate / pathology*,  physiopathology*
Female
Humans
Magnetic Resonance Imaging
Male
Phenotype
Sex Factors
Young Adult
Grant Support
ID/Acronym/Agency:
5 R01 DE014399-05/DE/NIDCR NIH HHS; R01 DE014399/DE/NIDCR NIH HHS
Comments/Corrections

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