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Is Abnormal 50g-Glucose Challenge Testing an Independent Predictor of Adverse Pregnancy Outcome?
MedLine Citation:
PMID:  22881605     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract OBJECTIVE: To determine whether an abnormal 50g-glucose challenge test (GCT) is independently associated with adverse pregnancy outcome. METHODS: A retrospective study of women with abnormal GCT (>140 mg/dl) but normal subsequent 100g-oral glucose tolerance test (OGTT). Pregnancy outcome was compared with that of women with normal GCT (<140 mg/dl). RESULTS: Of the 79,153 women delivered during the study period, the results of the GCT were available for 14,268. Of these, 809 (5.7%) had an abnormal GCT and normal OGTT and were eligible for the study group. An abnormal GCT was independently associated with an increased risk for macrosomia (OR=2.0, 95%-CI 1.5-2.7), LGA (OR=1.6, 95%-CI 1.3-2.0), cesarean section (OR=1.3, 95%-CI 1.1-1.6), respiratory morbidity (OR=1.6, 95%-CI 1.1-2.7) and neonatal hypoglycemia (OR=1.8, 95%-CI 1.1-3.2). In contrast, an abnormal GCT was associated with decreased risk for preterm delivery at less than 37 weeks (OR=0.7, 95%-CI 0.5-0.9) and 34 weeks (OR=0.3, 95%-CI 0.1-0.6). The association between abnormal GCT and adverse pregnancy outcome was unrelated to the degree of GCT abnormality except for cases in which the GCT was extremely high (>=180 mg/dl). CONCLUSION: Women with abnormal GCT result are at increased risk for adverse pregnancy outcome even in the presence of a normal subsequent OGTT.
Authors:
Nir Melamed; Liran Hiersch; Moshe Hod; Rony Chen; Arnon Wiznitzer; Yariv Yogev
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-13
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
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