Document Detail


Ablation of suprachiasmatic nucleus alters timing of hibernation in ground squirrels.
MedLine Citation:
PMID:  8790422     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hibernation patterns were monitored continuously for 2.5 years in female squirrels that were neurologically intact or in which the hypothalamic suprachiasmatic nucleus (SCN) was completely ablated (SCNx). The number of hibernation bouts in SCNx squirrels increased by 159%, total hibernation time increased by 58%, and periodic arousals from hibernation were 47% longer in SCNx than in control squirrels; the duration of individual torpor bouts was 2 days shorter and far more variable in SCNx than in control animals. Some SCNx squirrels cycled through bouts of torpor continuously for nearly 2 years. The SCN appears to be part of the mechanism that controls the duration of the hibernation season and the temporal structure of individual torpor bouts.
Authors:
N F Ruby; J Dark; H C Heller; I Zucker
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  93     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1996-10-24     Completed Date:  1996-10-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  9864-8     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, Stanford University, CA 94305, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Temperature Regulation
Female
Hibernation / physiology*
Periodicity
Sciuridae / physiology*
Suprachiasmatic Nucleus / physiology*,  surgery
Grant Support
ID/Acronym/Agency:
HD 07471/HD/NICHD NIH HHS; HD 14595/HD/NICHD NIH HHS; NS 30816/NS/NINDS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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