Document Detail


Ablation of the sphenopalatine ganglion does not attenuate the infarct reducing effect of vagus nerve stimulation.
MedLine Citation:
PMID:  23273773     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Electrical stimulation of the cervical vagus nerve reduces infarct size by approximately 50% after cerebral ischemia in rats. The mechanism of ischemic protection by vagus nerve stimulation (VNS) is not known. In this study, we investigated whether the infarct reducing effect of VNS was mediated by activation of the parasympathetic vasodilator fibers that originate from the sphenopalatine ganglion (SPG) and innervate the anterior cerebral circulation. We examined the effects of electrical stimulation of the cervical vagus nerve in two groups of rats: one with and one without SPG ablation. Electrical stimulation was initiated 30 min after induction of ischemia, and lasted for 1h. Measurement of infarct size 24h later revealed that the volume of ischemic damage was smaller in those animals that received VNS treatment (41.32±2.07% vs. 24.19±2.62% of the contralateral hemispheric volume, n=6 in both; p<0.05). SPG ablation did not abolish this effect; the reduction in infarct volume following VNS was 58% in SPG-damaged animals, 41% in SPG-intact animals (p>0.05). In both SPG-intact and SPG-damaged animals VNS treatment resulted in better motor outcome (p<0.05 vs. corresponding controls for both). Our findings show that VNS can protect the brain against acute ischemic injury, and that this effect is not mediated by SPG projections.
Authors:
Ilknur Ay; Hakan Ay
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-27
Journal Detail:
Title:  Autonomic neuroscience : basic & clinical     Volume:  174     ISSN:  1872-7484     ISO Abbreviation:  Auton Neurosci     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-11     Completed Date:  2013-08-28     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  100909359     Medline TA:  Auton Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Ablation Techniques
Animals
Behavior, Animal
Brain Ischemia / etiology,  therapy
Cerebral Infarction / metabolism,  pathology,  physiopathology,  prevention & control*
Cerebrovascular Circulation
Cerebrum / blood supply,  innervation*,  pathology
Ganglia, Autonomic / metabolism*,  surgery
Infarction, Middle Cerebral Artery / physiopathology
Male
Motor Activity
Psychomotor Disorders / etiology,  prevention & control
Pterygopalatine Fossa / innervation*,  surgery
Random Allocation
Rats
Rats, Wistar
Synaptic Transmission*
Vagus Nerve Stimulation*
Grant Support
ID/Acronym/Agency:
P41RR14075/RR/NCRR NIH HHS; R01 NS059710/NS/NINDS NIH HHS; R01NS059710/NS/NINDS NIH HHS; R21 NS081395/NS/NINDS NIH HHS
Comments/Corrections

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