| Ability of integrated positron emission and computed tomography to detect significant colonic pathology: the experience of a tertiary cancer center. | |
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MedLine Citation:
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PMID: 20143447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The ability of integrated positron emission tomography and computed axial tomography (PET-CT) to detect colonic pathology is not fully defined. The purpose of this study was to assess the ability of PET-CT to detect colonic pathology and to determine the significance of ((18)F)2-fluoro-2-deoxyglucose ((18)F-FDG) activity noted incidentally in the colon on PET-CT. METHODS: Records for all patients who underwent PET-CT and colonoscopy at our institution were reviewed. Patients with history of colonic malignancy or colon surgery were excluded. RESULTS: Fifty-eight patients had incidental colonic (18)F-FDG activity on PET (Group A) and 272 had none (Group B). In Group A, 65% of patients had pathologic findings detected on colonoscopy that corresponded to the site of PET activity. Standardized uptake value (SUV) readings were not helpful in distinguishing true-positives from false-positives. In Group B, 11.8% of patients were found to have significant colonic findings. Lesions not detected by PET-CT included 4 colon cancers, 7 advanced adenomas, and 10 patients with colonic lymphoma. Overall, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of PET-CT for detecting significant pathology were 53%, 93%, 65%, 89%, and 85%, respectively. For detecting colon cancer and adenomas 10 mm or more, the sensitivity, specificity, PPV, NPV, and accuracy of PET-CT were 72%, 90%, 45%, 96%, and 88%, respectively. CONCLUSIONS: Incidental colonic activity detected by PET-CT warrants further evaluation with colonoscopy. However, negative PET-CT does not rule out significant colonic pathology including colon cancer, advanced adenomas, or lymphoma. |
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Authors:
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Brian R Weston; Revathy B Iyer; Wei Qiao; Jeffrey H Lee; Robert S Bresalier; William A Ross |
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Publication Detail:
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Type: Evaluation Studies; Journal Article |
Journal Detail:
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Title: Cancer Volume: 116 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-04-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 1454-61 Citation Subset: AIM; IM |
Affiliation:
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Department of Gastroenterology, Hepatology and Nutrition, Unit 1466, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-1402, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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diagnosis Colon / radiography*, radionuclide imaging* Colonic Neoplasms / diagnosis* Colonoscopy Deoxyglucose / diagnostic use False Positive Reactions Female Humans Incidental Findings Lymphoma / diagnosis Male Middle Aged Positron-Emission Tomography / methods* Radiopharmaceuticals / diagnostic use Sensitivity and Specificity Tomography, X-Ray Computed* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 154-17-6/Deoxyglucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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