Document Detail

Ability of exercise to inhibit carbohydrate-induced hypertriglyceridemia in rats.
MedLine Citation:
PMID:  7015069     Owner:  NLM     Status:  MEDLINE    
The ability of spontaneous running to prevent carbohydrate-induced hypertriglyceridemia was studied in young, nonobese rats. Exercise-trained and sedentary rats were fed a diet consisting of (as percent total calories) 12% fat, 22% protein, and 66% carbohydrate. The source of the carbohydrate was varied, and experiments were carried out with sucrose and glucose as the sole dietary carbohydrate. Plasma triglyceride (TG) levels rose in response to both forms of dietary carbohydrate in both sedentary and exercise-trained rats, but the magnitude of the elevation was greatly attenuated in the exercise-trained group. Plasma insulin concentrations were also significantly lower in exercise-trained rats. Measurements of hepatic very low density lipoprotein (VLDL)-TG secretion rate and adipose tissue lipoprotein lipase (LPL) activity were made in an effort to determine how exercise-training prevented the development of carbohydrate-induced hypertriglyceridemia. The results of these studies indicated that perfused livers of exercise-trained rats secreted significantly less VLDL-TG, whereas adipose tissue LPL activity of the two groups was similar. On the basis of these results, it is postulated that the ability of exercise-training to inhibit carbohydrate-induced hypertriglyceridemia is due to an increase in insulin sensitivity resulting from chronic exercise. As a result, the postprandial insulin responses to high carbohydrate diets would be relatively reduced in exercise-trained rats, leading to decreased hepatic VLD-TG secretion, and lower plasma triglyceride concentrations.
I Zavaroni; Y I Chen; C E Mondon; G M Reaven
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  30     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1981 May 
Date Detail:
Created Date:  1981-07-09     Completed Date:  1981-07-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  476-80     Citation Subset:  IM    
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MeSH Terms
Adipose Tissue / enzymology
Dietary Carbohydrates / pharmacology*
Glucose / pharmacology
Insulin / blood
Lipoprotein Lipase / metabolism
Lipoproteins, VLDL / secretion
Liver / secretion
Physical Exertion*
Sucrose / pharmacology
Triglycerides / blood*,  secretion
Grant Support
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Lipoproteins, VLDL; 0/Triglycerides; 11061-68-0/Insulin; 50-99-7/Glucose; 57-50-1/Sucrose; EC Lipase

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