| Ability of orally administered IFN-α4 to inhibit naturally occurring gingival inflammation in dogs. | |
| | |
MedLine Citation:
|
PMID: 20424396 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
It has been reported that type I interferons (IFN-α/β) play an important role in innate immune responses against viral and bacterial infections. In this study, we used and examined naturally occurred canine periodontal disease to show the therapeutic efficacy of low dose oral administration (LDOA) of canine IFN-α subtype 4 (CaIFN-α4). We administered purified recombinant CaIFN-α4 expressed in a baculovirus system to dogs with or without gingival inflammation. We found that LDOA of CaIFN-α4 reduce periodontopathic bacterial counts. LDOA induced improvement of naturally occurring gingival inflammation, and reduction of the stress marker responses was also observed after LDOA. These results suggest that LDOA of CaIFN-α4 has effectiveness for improvement of naturally occurring gingival inflammation in dogs. |
| | |
Authors:
|
Akira Ito; Emiko Isogai; Kuniaki Yoshioka; Ko Sato; Naomi Himeno; Toru Gotanda |
Related Documents
:
|
9316996 - Porphyromonas gingivalis infection of oral epithelium inhibits neutrophil transepitheli... 7597416 - Biological activities of lipopolysaccharides from oral bacteria and their relevance to ... 12760506 - Periodontal disease: links with serum lipid/ triglyceride levels? review and new data. 19210336 - Salivary cytokine levels in subjects with chronic periodontitis and in periodontally he... 19833056 - Interleukin-21 in t cell-mediated diseases. 17381396 - Cardiac mitochondrial damage and inflammation responses in sepsis. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-16 |
Journal Detail:
|
Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 72 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-10-08 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: Japan |
Other Details:
|
Languages: eng Pagination: 1145-51 Citation Subset: IM |
Affiliation:
|
Research Institute of Genome-Based Biofactory, National Institute of Advanced Industrial and Science Technology (AIST), Sapporo, Hokkaido, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of Breath-Hold on Blood Gas Analysis in Captive Pacific White-Sided Dolphins (Lagenorhynchus ...
Next Document: Hypertension update and cardiovascular risk reduction in physically active individuals and athletes.