| Ability of 18F-FDG PET/CT to diagnose recurrent colorectal cancer in patients with elevated CEA concentrations. | |
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MedLine Citation:
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PMID: 20364373 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Elevated levels of serum carcinoembryonic antigen (CEA) in patients with colorectal cancer (CRC) during follow-up suggest recurrence, which can be visualized by (18)F-FDG PET/CT. Since the magnitude of CEA elevation reflects cancer volume, the ability of PET/CT to detect recurrence in patients with only mildly elevated CEA might be limited. However, the accuracy of PET/CT in detecting recurrence associated with elevated CEA has not been fully assessed. We retrospectively evaluated the diagnostic performance of (18)F-FDG PET/CT postoperatively relative to CEA levels among patients with CRC. METHODS: We visually assessed 75 PET/CT evaluations of 57 postoperative patients with CEA >5.0 ng/ml. Tumor volumes were also determined using image analysis software. The final diagnosis was confirmed based on histopathological findings, or at least on 6 months of clinical follow-up. RESULTS: Two lung cancers were excluded and we finally analyzed data from 73 of the 75 PET/CT evaluations. Recurrences were diagnosed in 54 (prevalence 74%). The sensitivity and specificity of PET/CT to detect recurrence was 50/54 (93%) and 14/19 (74%), respectively. The positive and negative predictive values were 91 and 78%, respectively, and the positive and negative likelihood ratios were 3.52 and 0.10, respectively. Values for the sensitivity of PET/CT were 88 and 95%, and those for specificity were 78 and 70%, at serum CEA concentrations of 5-10 and >10 ng/ml, respectively. Serum CEA (r = 0.500, p < 0.001) significantly correlated with cancer volumes. CONCLUSIONS: The present findings showed that (18)F-FDG PET/CT could accurately detect recurrent CRC irrespective of the elevated CEA concentration. |
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Authors:
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Yukishige Kyoto; Mitsuru Momose; Chisato Kondo; Michio Itabashi; Shingo Kameoka; Kiyoko Kusakabe |
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Publication Detail:
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Type: Journal Article Date: 2010-04-03 |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 24 ISSN: 1864-6433 ISO Abbreviation: Ann Nucl Med Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-15 Completed Date: 2010-09-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 395-401 Citation Subset: IM |
Affiliation:
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Department of Radiology, Japan Self-Defense Forces Central Hospital, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Carcinoembryonic Antigen / blood* Colorectal Neoplasms / blood*, diagnosis*, pathology, surgery False Negative Reactions False Positive Reactions Female Fluorodeoxyglucose F18 / diagnostic use* Humans Male Middle Aged Positron-Emission Tomography* Recurrence Retrospective Studies Tomography, X-Ray Computed* Tumor Burden |
| Chemical | |
Reg. No./Substance:
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0/Carcinoembryonic Antigen; 63503-12-8/Fluorodeoxyglucose F18 |
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