| Aberrations in Plasma Phospholipid Fatty Acids in Lung Cancer Patients. | |
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MedLine Citation:
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PMID: 22160451 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abnormalities in lipid metabolism have been frequently observed in cancer and are associated with a poor prognosis. However, a detailed, longitudinal characterization of fatty acid status is lacking. This study aimed to assess plasma phospholipid fatty acids before chemotherapy, immediately after and 1 month following chemotherapy in a group of 50 patients newly diagnosed with lung cancer and explore factors which may contribute to aberrations in fatty acids. Their mean ± SD characteristics: age 64 ± 8.5 years, 75% advanced stage disease, body mass index 27.0 ± 5.4 kg/m(2), 6 month weight loss -4.6 ± 6.1%. Compared to patients with early stage disease, patients with advanced disease had abnormal fatty acid profiles including significantly lower (P < 0.05) amounts of total phospholipid fatty acids, saturated, and polyunsaturated fatty acids (linoleic, arachidonic, eicosapentaenoic and docosahexaenoic). Longitudinal analysis revealed that patients with advanced disease who completed chemotherapy had stable fatty acid levels and continued to maintain levels 1 month following completion of chemotherapy. Comparatively, patients who did not complete chemotherapy due to toxicity or disease progression had progressive loss of total phospholipid fatty acids, stearic, linoleic and n-6 fatty acids and a trend towards lower docosahexaenoic, arachidonic, palmitic, n-3 and saturated fatty acids. These results suggest that loss of fatty acids is prevalent, progressive and potentially influenced by advanced disease and chemotherapy treatment. |
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Authors:
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Rachel A Murphy; Taylor F Bureyko; Marina Mourtzakis; Quincy S Chu; M Thomas Clandinin; Tony Reiman; Vera C Mazurak |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-10 |
Journal Detail:
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Title: Lipids Volume: - ISSN: 1558-9307 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0060450 Medline TA: Lipids Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Agricultural, Food and Nutritional Science, University of Alberta, 4-126A Li Ka Shing Centre, Edmonton, AB, T6G 2E1, Canada. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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