| Aberrant methylation of the CpG island of HLTF gene in gastric cardia adenocarcinoma and dysplasia. | |
| | |
MedLine Citation:
|
PMID: 21531217 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: To investigate the promoter methylation of HLTF in the tissues and plasma of patients with gastric cardia adenocarcinoma (GCA) and dysplasia. DESIGN AND METHODS: Nested MSP approach was used to detect HLTF methylation status. RESULTS: The frequency of HLTF methylation in high grade dysplasia and GCA tumor tissues was significantly higher than that in chronic inflammation tissues and was significantly associated with upper gastrointestinal cancers (UGIC) family history and protein and mRNA expression of the gene. HLTF methylation was not found in the plasma of patients with chronic inflammation and low grade dysplasia, while 4.0% (1/25) of patients with high grade dysplasia and 20.8% of (20/96) GCA patients were detected with hypermethylation of HLTF in the plasma. CONCLUSIONS: In all, HLTF methylation may exist in gastric cardia dysplasia stages and may play important role in the development of GCA especially in individuals with UGIC family history. |
| | |
Authors:
|
Wei Guo; Zhiming Dong; Yanli Guo; Zhifeng Chen; Gang Kuang; Zhibin Yang |
Related Documents
:
|
15480107 - Does comorbidity explain trends in prescribing of newer antihypertensive agents? 6169277 - Mineralocorticoid hypertension due to a nasal spray containing 9 alpha-fluoroprednisolone. 6363097 - Nifedipine in the treatment of hypertension. 23105497 - Lipid peroxide levels and antioxidant status in alcoholic liver disease. 3987137 - Neuromuscular complications in patients given pavulon (pancuronium bromide) during arti... 11380227 - Can 8-oxo-dg be used as a predictor for individual radiosensitivity? |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-22 |
Journal Detail:
|
Title: Clinical biochemistry Volume: - ISSN: 1873-2933 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Inc. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Establishment of reference intervals for bone markers in children and adolescents.
Next Document: Influence of pre-analytical factors on ?-galactosidase A, arylsulfatase B and ?-glucosidase activiti...