Document Detail

Aberrant intrinsic brain activity and cognitive deficit in first-episode treatment-naive patients with schizophrenia.
MedLine Citation:
PMID:  22883428     Owner:  NLM     Status:  Publisher    
BACKGROUND: Given the important role of the default mode network (DMN) in cognitive function and the well-known neurocognitive deficit in schizophrenia, it is intriguing to examine systematically the relationship between neurocognitive dysfunction and aberrant intrinsic activities, and also functional connectivity, of the DMN in patients with schizophrenia. Method First-episode, treatment-naive patients with schizophrenia (FES) (n=115) and healthy controls (n=113) underwent resting-state functional magnetic resonance imaging (fMRI) scans and neurocognitive tests. Intrinsic neural activities evaluated by using the fragment amplitude of low-frequency fluctuations (fALFF) and the resting-state functional connectivity assessed by seed-based correlational analysis were compared between patients and controls. Aberrant intrinsic activities and DMN connectivity in patients were then correlated to neurocognitive performance and clinical symptoms. RESULTS: Compared to controls, patients with FES showed decreased fALFF in the bilateral medial prefrontal cortex (MPFC) and the orbitofrontal cortex (OFC), and increased fALFF in the bilateral putamen. Increased functional connectivity with the DMN was observed in the left insula and bilateral dorsolateral PFC (DLPFC) in patients with FES. In patients, aberrant fALFF in the bilateral OFC were correlated with cognitive processing speed; fALFF in the left OFC and right putamen were correlated with the clinical factors excited/activation and disorganization; and increased DMN functional connectivity in the left insula was correlated with the clinical factors positive, excited/activation, disorganization and neurocognitive deficit in the domain of sustained attention. CONCLUSIONS: These associations between neurocognitive dysfunction and aberrant intrinsic activities, and also functional connectivity, of the DMN in patients with schizophrenia may provide important insights into the neural mechanism of the disease.
Z He; W Deng; M Li; Z Chen; L Jiang; Q Wang; C Huang; D A Collier; Q Gong; X Ma; N Zhang; T Li
Related Documents :
10710868 - Reproductive outcome following hysteroscopic lysis of intrauterine adhesions: a result ...
6448648 - The value of laparoscopy under local anaesthesia in 250 medical and surgical patients.
6445178 - Laparoscopy for questionable appendicitis: can it reduce the negative appendectomy rate?
22640978 - Multiple mdma (ecstasy) overdoses at a rave event: a case series.
25277318 - Differences in cardiac autonomic function contributes to heart rate abnormalities in po...
21095198 - The executive control of attention differentiates patients with schizophrenia, their fi...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-10
Journal Detail:
Title:  Psychological medicine     Volume:  -     ISSN:  1469-8978     ISO Abbreviation:  Psychol Med     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-12     Citation Subset:  -    
The Mental Health Center and the Psychiatric Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Low-temperature synthesis of multilayer graphene/amorphous carbon hybrid films and their potential a...
Next Document:  Short-term results of laparoscopic surgery after preoperative chemoradiation for clinically staged T...