Document Detail

Aberrant folate status in schizophrenic patients: what is the evidence?
MedLine Citation:
PMID:  16111796     Owner:  NLM     Status:  MEDLINE    
A vast amount of case reports, open studies and, to a lesser extent, case-control studies have been published on the topic of psychopathology and folate deficiency. These studies reported a high incidence of serum folate deficiency in patients with various psychiatric disorders. Folate deficiency seems to be a particular consistent finding in depressive patients. The evidence for an association between aberrant folate status and schizophrenia seems less convincing. The lack of stringent methodology such as inclusion of age- and sex-matched controls was thought to be the main reason for the inconclusive results. The purpose of this article is to review the published case-control studies that provide data on folate levels in the population of patients with schizophrenia. Data extracted from these studies comprised methodological design, clinical characteristics and folate measurements. We found that none of the 7 case-control studies included in this review (in total 325 cases and 560 control subjects) explicitly reported on all critical factors in the assessment of folate. In addition, only three studies found lower plasma folate levels more frequently in patients with schizophrenia compared to controls. Further research on this topic is required to clarify the relationship between folate status and schizophrenia and should avoid the methodological pitfalls mentioned in this review. In addition, research should also focus on polymorphisms of genes related to folate metabolism.
Jan-Willem Muntjewerff; Henk J Blom
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  29     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-10-03     Completed Date:  2006-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  1133-9     Citation Subset:  IM    
GGz Nijmegen, Mental Health Institute Nijmegen, P.O. Box 7049, 6503 GM Nijmegen, The Netherlands.
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MeSH Terms
Folic Acid / metabolism*
Folic Acid Deficiency / complications*,  genetics,  metabolism*
Schizophrenia / complications*,  metabolism*
Reg. No./Substance:
59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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