| Aberrant expression of miR-196a in gastric cancers and correlation with recurrence. | |
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MedLine Citation:
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PMID: 22420029 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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MicroRNAs (miRNAs) are short noncoding RNAs (~22 nt) that play important roles in the pathogenesis of human diseases by negatively regulating gene expression. Here, we examined the relationship between miR-196a and gastric cancer.By the analysis of 72 gastric cancer samples, we found that the expression level of miR-196a microRNA significantly increased in primary gastric cancer tissues versus adjacent normal tissues. In addition, extracellular miR-196a detected in conditioned medium was strongly correlated with its cellular expression status and increased circulating miR-196a in patient serum was associated with gastric cancer disease status and relapse. Furthermore, ectopic expression of miR-196a microRNA promoted the epithelial-mesenchymal transition and migration/invasion capabilities of transfected cells, suggesting its oncogenic potential in gastric cancer progression. Altogether, our data demonstrate that miR-196a exerts an oncogenic role in gastric cancer and miR-196a may be a novel biomarker for detecting gastric cancer and for monitoring disease recurrence. |
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Authors:
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Kuo-Wang Tsai; Yu-Lun Liao; Chew-Wun Wu; Ling-Yueh Hu; Sung-Chou Li; Wen-Ching Chan; Meng-Ru Ho; Chun-Hung Lai; Hsiao-Wei Kao; Wen-Liang Fang; Kuo-Hung Huang; Wen-Chang Lin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Genes, chromosomes & cancer Volume: 51 ISSN: 1098-2264 ISO Abbreviation: Genes Chromosomes Cancer Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-03-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9007329 Medline TA: Genes Chromosomes Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 394-401 Citation Subset: IM |
Copyright Information:
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© 2011 Wiley Periodicals, Inc. |
Affiliation:
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Department of Medical Education and Research, KaohsiungVeterans General Hospital, Kaohsiung, Taiwan, Republic of China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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