| Aberrant expression of the apoptosis-related proteins BAK and MCL1 in T cells in multiple sclerosis. | |
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MedLine Citation:
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PMID: 22257632 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Pathogenic T cells of multiple sclerosis (MS) patients have been suggested to be endowed with an increased resistance to apoptosis, contributing to their increased survival. We report herein increased levels of the anti-apoptotic MCL1 protein and its half-life in activated lymphocytes of MS patients, which were not associated with differences in MCL1 RNA levels or with alterations in the expression levels of the known E3 ligases of MCL1-β-TrCP and HUWE1. Concomitantly, the expression levels of the pro-apoptotic protein BAK were decreased in MS patients at relapse. These findings suggest the dysregulation of the apoptosis-related proteins MCL1 and BAK in MS. |
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Authors:
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Ilana Mandel; Tamar Paperna; Ariel Miller |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-16 |
Journal Detail:
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Title: Journal of neuroimmunology Volume: - ISSN: 1872-8421 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Carmel Medical Center, Haifa, Israel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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