Document Detail

Aberrant expression of alpha-fetoprotein in intrahepatic cholangiocarcinoma: an exceptional occurrence.
MedLine Citation:
PMID:  18417680     Owner:  NLM     Status:  MEDLINE    
A high level of serum alpha-fetoprotein (AFP) is typically indicative of hepatocellular carcinoma in patients with liver lesions. In this article, we describe an exceptional case of intrahepatic cholangiocarcinoma that occurred in a 36-year-old man with a markedly elevated serum AFP level (12310.7 ng/mL). Histopathologic examination of surgically resected liver mass showed classic morphologic features of cholangiocarcinoma, with no hepatocellular carcinoma component identified. Immunohistochemically, the tumor cells were strongly and diffusely positive for AFP, CA19-9, and cytokeratin 19 and were negative for hepatocyte antigen. The patient's serum AFP level declined to 46.2 ng/mL 1 month after surgery. To the best of our knowledge, this is the first documented case of AFP-producing intrahepatic cholangiocarcinoma with immunohistochemical evidence confirming the tumor cells to be the source of high-level AFP production.
Kiran Vij; Hanlin L Wang
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  International journal of surgical pathology     Volume:  16     ISSN:  1066-8969     ISO Abbreviation:  Int. J. Surg. Pathol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-17     Completed Date:  2008-06-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9314927     Medline TA:  Int J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  194-8     Citation Subset:  IM    
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
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MeSH Terms
Bile Duct Neoplasms / metabolism*,  pathology,  surgery
Bile Ducts, Intrahepatic / metabolism*,  pathology
Cholangiocarcinoma / metabolism*,  pathology,  surgery
Neoplasm Proteins / metabolism
Tomography, X-Ray Computed
Tumor Markers, Biological / metabolism
alpha-Fetoproteins / metabolism*
Reg. No./Substance:
0/Neoplasm Proteins; 0/Tumor Markers, Biological; 0/alpha-Fetoproteins

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