Document Detail


Aberrant expression of T-plastin in Sezary cells.
MedLine Citation:
PMID:  14612505     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mycosis fungoides (MF) and its leukemic variant, Sezary syndrome (SS), are the most common cutaneous T-cell lymphomas, with a combined incidence of 0.36 of 100,000 person-years. Although thought to be closely related to mature T-helper cells, the true nature of the cancer cells in MF/SS is unknown. In addition, there is no known specific marker for MF/SS cancer cells, which can result in difficulties in the diagnosis and treatment. To identify MF/SS-specific markers, Sezary cancer cells were analyzed with a global genomic screening tool, the modified representational difference analysis. It was discovered that unlike T-helper cells from healthy individuals or patients with nonmalignant dermatoses, Sezary cells from most patients with Sezary syndrome aberrantly expressed T-plastin mRNA and protein. This is the first time T-plastin protein, a cytoplasmic protein regulating actin assembly and cellular motility, has been detected in the hematopoietic cells. Therefore, T-plastin has the potential to be a Sezary cell-specific marker valuable for diagnostic and treatment of Sezary syndrome.
Authors:
Ming-wan Su; Irene Dorocicz; Wieslawa H Dragowska; Vincent Ho; Gang Li; Nicolas Voss; Randy Gascoyne; Youwen Zhou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  63     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-12     Completed Date:  2004-01-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7122-7     Citation Subset:  IM    
Affiliation:
Chieng Genomics Centre, Laboratory of Predictive Medicine and Therapeutics, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, V5Z 4E8 Canada.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Female
Humans
Male
Membrane Glycoproteins
Microfilament Proteins
Middle Aged
Phosphoproteins / biosynthesis*,  genetics
Protein Isoforms
RNA, Messenger / biosynthesis,  genetics
Sezary Syndrome / blood,  genetics,  metabolism*,  pathology
T-Lymphocytes, Helper-Inducer / metabolism,  physiology
Tumor Markers, Biological / biosynthesis,  genetics
Chemical
Reg. No./Substance:
0/Membrane Glycoproteins; 0/Microfilament Proteins; 0/Phosphoproteins; 0/Protein Isoforms; 0/RNA, Messenger; 0/Tumor Markers, Biological; 0/plastin

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