| Aberrant expression of Fas and FasL pro-apoptotic proteins in basal cell and squamous cell carcinomas. | |
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MedLine Citation:
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PMID: 20497185 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background. Fas and FasL are cell-surface receptors involved in apoptosis. Aim. To investigate Fas and FasL expression levels in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) to gain an insight into the mechanisms of Fas/FasL apoptosis and immune evasion in epidermal tumours. Methods. Real-time PCR and streptavidin-biotin immunohistochemistry techniques were used to detect Fas and FasL expression in BCC, SCC and normal skin specimens. Results. Fas and FasL mRNA expression and immunostaining levels were lower in the 21 BCC specimens than in normal skin, whereas they were higher in the 15 SCC specimens than in normal skin. Conclusion. FasL immunostaining correlated with the capability of the tumour to invade and metastasize; the absent or weak immunostaining in the BCC specimens correlated with low capability, and the strong staining in the SCC specimens correlated with high capability. |
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Authors:
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X-Y Wang; R Zhang; S Lian |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental dermatology Volume: 36 ISSN: 1365-2230 ISO Abbreviation: Clin. Exp. Dermatol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7606847 Medline TA: Clin Exp Dermatol Country: England |
Other Details:
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Languages: eng Pagination: 69-76 Citation Subset: IM |
Copyright Information:
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© 2010 The Author(s). Journal compilation © 2010 British Association of Dermatologists. |
Affiliation:
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Department of Dermatology and Venerology, The Affiliated Hospital of Inner Mongolia Medical College, Hohhot, China Department of Dermatology and Venerology, Xuan Wu Hospital, Capital Medical University, Beijing, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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