Document Detail

Aberrant cytokine production by peripheral blood mononuclear cells in recurrent pregnancy loss?
MedLine Citation:
PMID:  12202438     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Successful pregnancy may depend on a Th2-type cytokine response, whilst, conversely, a poor pregnancy outcome may be associated with an increase in Th1 cytokines and a concomitant decrease in Th2 cytokines. This prospective study was designed to elucidate whether a failure of the cytokine shift pre-dated miscarriage and was therefore likely to be an aetiological factor in recurrent pregnancy loss (RPL). METHODS: Cytokine production by stimulated peripheral blood mononuclear cells from 46 pregnant women who had previously suffered idiopathic RPL during early pregnancy was compared with 25 gestationally age-matched pregnant controls and 11 non-pregnant women. RESULTS: Production of IFN-gamma was lower in pregnant than in non-pregnant women and even lower in RPL pregnant women (P = 0.0191). IL-10 was increased in pregnant women compared with non-pregnant controls, and further increased in RPL patients (P = 0.026). IL-4 was also increased in women with RPL (P = 0.0001). No differences in IFN-gamma, IL-10 or IL-4 secretion were observed in RPL patients who subsequently miscarried compared with those who successfully completed the pregnancy. RPL women with a successful reproductive outcome had similar concentrations of TNF-alpha to pregnant women, RPL women who subsequently miscarried had significantly lower levels than either pregnant women (P = 0.02) or non-pregnant controls (P = 0.0004). CONCLUSIONS: Contrary to our hypothesis, the cytokine shift, which appears to characterize normal pregnancy, was accentuated rather than diminished in RPL pregnant women.
M D Bates; S Quenby; K Takakuwa; P M Johnson; G S Vince
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  17     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-30     Completed Date:  2003-03-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2439-44     Citation Subset:  IM    
Department of Immunology, University of Liverpool, L69 3BX, UK.
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MeSH Terms
Abortion, Habitual / blood*
Cytokines / biosynthesis*
Interferon-gamma / biosynthesis
Interleukin-10 / biosynthesis
Interleukin-4 / biosynthesis
Monocytes / metabolism*
Prospective Studies
Reference Values
Tumor Necrosis Factor-alpha / biosynthesis
Reg. No./Substance:
0/Cytokines; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma

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