Document Detail


Aberrant cytokine expression in serum of patients with adenoid cystic carcinoma and squamous cell carcinoma of the head and neck.
MedLine Citation:
PMID:  17111427     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Squamous cell carcinoma (SCC) and adenoid cystic carcinoma (ACC) represent 2 clinically important subtypes of head and neck cancer. Our objective was to characterize and compare cytokine profiles in the systemic circulation of patients with SCC and ACC. METHODS: Multiplex analysis of 10 different cytokines (interleukin [IL]-1beta, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, granulocyte-macrophage colony-stimulating factor [GM-CSF], interferon [IFN]-gamma, and tumor necrosis factor [TNF]-alpha) in the serum of patients with SCC (n = 20) and ACC (n = 20) and healthy controls (n = 20) was performed using the Luminex fluorescent-bead technology. RESULTS: Patients with SCC as well as patients with ACC showed an altered cytokine profile compared with healthy individuals. In patients with SCC, significantly elevated serum levels of the proinflammatory cytokines, IL-6 and IL-8, were observed. In patients with ACC, IL-8 serum levels were significantly elevated, and IL-6 serum levels were only increased in a subset of patients. CONCLUSIONS: A similar serum cytokine profile, with the predominance of proinflammatory cytokines, was observed in patients with SCC and ACC. The newly defined cytokine profile in ACC patients may form the basis for future investigations to explore the role of cytokines in ACC tumor progression and their potential value as predictive biomarkers.
Authors:
Thomas K Hoffmann; Eniko Sonkoly; Bernhard Homey; Katrin Scheckenbach; Christian Gwosdz; Murat Bas; Adam Chaker; Kerstin Schirlau; Theresa L Whiteside
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Head & neck     Volume:  29     ISSN:  1043-3074     ISO Abbreviation:  Head Neck     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-10     Completed Date:  2007-06-19     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8902541     Medline TA:  Head Neck     Country:  United States    
Other Details:
Languages:  eng     Pagination:  472-8     Citation Subset:  IM    
Copyright Information:
(c) 2006 Wiley Periodicals, Inc.
Affiliation:
Department of Otorhinolaryngology, Heinrich-Heine-University, D-40225 Düsseldorf, Germany. tkhoffmann@uni-duesseldorf.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Carcinoma, Adenoid Cystic / blood*,  pathology
Carcinoma, Squamous Cell / blood*,  pathology
Case-Control Studies
Cytokines / blood*
Female
Head and Neck Neoplasms / blood*,  pathology
Humans
Male
Middle Aged
Tumor Markers, Biological / blood
Grant Support
ID/Acronym/Agency:
P01 DE 12321/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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