Document Detail

Aberrant adiposity and ectopic lipid deposition characterize the adult phenotype of the preterm infant.
MedLine Citation:
PMID:  21772225     Owner:  NLM     Status:  MEDLINE    
Our investigation addresses the hypothesis that disruption of third trimester development by preterm birth alters multiple biological pathways affecting metabolic health in adult life. We compared healthy adult volunteers aged 18-27 y born at ≤ 33 wk gestation or at term. We used whole-body MRI, (1)H magnetic resonance spectroscopy (MRS) of liver and muscle, metabonomic profiling of blood and urine, and anthropometric and blood pressure measurements. Preterm subjects had greater (mean difference (95% CI)) total [2.21 L (0.3, 4.1), p = 0.03] and abdominal adipose tissue [internal 0.51 (0.1, 0.9), p = 0.007]; blood pressure [systolic 6.5 mm Hg (2.2, 10.8), p = 0.004; diastolic 5.9 (1.8, 10.1), p = 0.006]; and ectopic lipid (ratio (95% CI)), intrahepatocellular lipid (IHCL) 3.01 (1.78, 5.28) p < 0.001, and tibialis-intramyocellular lipid (T-IMCL) [1.31 (1.02, 1.69) p = 0.04]. In preterm, compared with term men, there was greater internal adipose tissue [mean (SD); men: preterm 4.0 (1.6), term 2.7 (1.1) liters; women: preterm 2.6 (0.9); term 2.6 (0.5); gender-gestation interaction p = 0.048] and significant differences in the urinary metabolome (elevated methylamines and acetyl-glycoproteins, lower hippurate). We have identified multiple premorbid biomarkers in ex-preterm young adults, which are most marked in men and indicative of risks to later wellbeing. These data offer insight into biological trajectories affected by preterm birth and/or neonatal care.
E Louise Thomas; James R Parkinson; Matthew J Hyde; Ivan K S Yap; Elaine Holmes; Caroline J Doré; Jimmy D Bell; Neena Modi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatric research     Volume:  70     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-10-10     Completed Date:  2012-02-07     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  507-12     Citation Subset:  IM    
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MeSH Terms
Adiposity / physiology*
Biological Markers / metabolism*
Blood Pressure
Glycoproteins / urine
Hippurates / urine
Infant, Newborn
Infant, Premature / physiology*
Lipids / analysis
Liver / metabolism
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy
Methylamines / urine
Muscles / metabolism
Sex Factors
Grant Support
MC_U120061305//Medical Research Council
Reg. No./Substance:
0/Biological Markers; 0/Glycoproteins; 0/Hippurates; 0/Lipids; 0/Methylamines; TE0865N2ET/hippuric acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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