Document Detail

Aberrant H-2-like allospecificities on K36.16 thymoma. Studies by radiobinding and immunoprecipitation with anti-H-2 monoclonal antibodies.
MedLine Citation:
PMID:  3819447     Owner:  NLM     Status:  MEDLINE    
The K36.16 thymoma expresses an H-2Dd-like allospecificity as detected by the 34-5-8 monoclonal antibody directed against H-2Dd using immunoprecipitation techniques. This monoclonal antibody gives a negative result by radio-immune assay but other anti-Dd antibodies react positively with this tumour. These results confirm and extend previous observations and are attributed to probable gene-conversion events possibly involving a donor gene from the Qa/Tla region, the products of which cross-react with Dd.
H Festenstein; K M Hui
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of immunogenetics     Volume:  13     ISSN:  0305-1811     ISO Abbreviation:  J. Immunogenet.     Publication Date:    1986 Apr-Jun
Date Detail:
Created Date:  1987-04-13     Completed Date:  1987-04-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0425125     Medline TA:  J Immunogenet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  113-6     Citation Subset:  IM    
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MeSH Terms
Antibodies, Monoclonal
Antigens, Neoplasm* / genetics
Cells, Cultured
Cross Reactions
Gene Conversion
H-2 Antigens* / genetics
Mice, Inbred AKR
Thymoma / genetics,  immunology*
Thymus Neoplasms / genetics,  immunology*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antigens, Neoplasm; 0/H-2 Antigens

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