Document Detail


Aberrance and modification of alpha-1- and alpha-2-globin gene expression in human and mouse erythroleukemia cells.
MedLine Citation:
PMID:  2117325     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In contrast to normal human erythroid tissues where the alpha 2:alpha 1-globin mRNA ratio is about 72:28, in human erythroleukemia K562 cells this ratio was found to be quite low, i.e. about 8:92. The ratio was moderately increased by hemin induction and approached almost normal levels after chromosomal transfer from K562 to the mouse erythroleukemia (MEL) cells. We suggest that operationally positive regulatory factors may exist in erythroleukemia cells, modifying the relative alpha 1- and alpha 2-globin gene expression by events following induction and by the adult MEL environment. These factors may act by altering the relative rate of alpha 1- and alpha 2-globin mRNA synthesis.
Authors:
A Mamalaki; N Moschonas
Related Documents :
19482015 - The alpha-hemoglobin stabilizing protein and expression of unstable alpha-hb variants.
21905285 - Oldenlandia diffusa ameliorates dextran sulphate sodium-induced colitis through inhibit...
519845 - Laboratory diagnosis of hb cc-alpha-thalassemia.
21751235 - Neuroimmunomodulative properties of dipeptidyl peptidase iv/cd26 in a tnbs-induced mode...
23184615 - Defective bile salt biosynthesis and hydroxylation in mice with reduced cytochrome p450...
15464745 - Distinct patterns of fos expression induced by systemic amphetamine in the striatal com...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta haematologica     Volume:  84     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1990  
Date Detail:
Created Date:  1990-09-20     Completed Date:  1990-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  30-7     Citation Subset:  IM    
Affiliation:
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion, Crete, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Line
Gene Expression Regulation, Neoplastic / drug effects,  genetics*
Globins / drug effects,  genetics*
Hemin / pharmacology
Humans
Hybrid Cells / drug effects
Leukemia, Erythroblastic, Acute / genetics*
Mice
Plasmids / genetics
RNA, Neoplasm / analysis,  drug effects,  genetics,  isolation & purification
RNA, Nuclear / analysis,  drug effects,  genetics,  isolation & purification
Transcription, Genetic / drug effects,  genetics
Tumor Cells, Cultured / drug effects
Chemical
Reg. No./Substance:
0/RNA, Neoplasm; 0/RNA, Nuclear; 16009-13-5/Hemin; 9004-22-2/Globins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pregnancy-associated thrombocytopenia: definition, incidence and natural history.
Next Document:  Erythrocytosis associated with renal artery thrombosis in a patient with polycystic kidney disease o...