Document Detail

Aberrance and modification of alpha-1- and alpha-2-globin gene expression in human and mouse erythroleukemia cells.
MedLine Citation:
PMID:  2117325     Owner:  NLM     Status:  MEDLINE    
In contrast to normal human erythroid tissues where the alpha 2:alpha 1-globin mRNA ratio is about 72:28, in human erythroleukemia K562 cells this ratio was found to be quite low, i.e. about 8:92. The ratio was moderately increased by hemin induction and approached almost normal levels after chromosomal transfer from K562 to the mouse erythroleukemia (MEL) cells. We suggest that operationally positive regulatory factors may exist in erythroleukemia cells, modifying the relative alpha 1- and alpha 2-globin gene expression by events following induction and by the adult MEL environment. These factors may act by altering the relative rate of alpha 1- and alpha 2-globin mRNA synthesis.
A Mamalaki; N Moschonas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta haematologica     Volume:  84     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1990  
Date Detail:
Created Date:  1990-09-20     Completed Date:  1990-09-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  30-7     Citation Subset:  IM    
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion, Crete, Greece.
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MeSH Terms
Cell Line
Gene Expression Regulation, Neoplastic / drug effects,  genetics*
Globins / drug effects,  genetics*
Hemin / pharmacology
Hybrid Cells / drug effects
Leukemia, Erythroblastic, Acute / genetics*
Plasmids / genetics
RNA, Neoplasm / analysis,  drug effects,  genetics,  isolation & purification
RNA, Nuclear / analysis,  drug effects,  genetics,  isolation & purification
Transcription, Genetic / drug effects,  genetics
Tumor Cells, Cultured / drug effects
Reg. No./Substance:
0/RNA, Neoplasm; 0/RNA, Nuclear; 16009-13-5/Hemin; 9004-22-2/Globins

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