Document Detail

Abdominal vagotomy disrupts food-related drinking in the rat.
MedLine Citation:
PMID:  670449     Owner:  NLM     Status:  MEDLINE    
Rats with complete subdiaphragmatic bilateral transection of the abdominal vagus (Vgx-C) showed disordered food-related drinking when drinking water in temporal association with a meal of dry food after 5-hr food deprivation and when drinking water in association with a liquid meal after 24-hr food deprivation. The Vgx-C rats drank after significantly longer latencies and drank significantly less water in 1 hr than did sham-vagotomized (Sham) rats after eating the same size meal (solid or liquid) as Shams. Rats with incomplete vagal transection (Vgx-I) ate and drank like Shams. Water intake of Sham and Vgx-I rats correlated positively with the meal size of solid food, but the water intake of Vgx-C rats did not. The failure of Vgx-C rats to drink water normally when food was ingested was not due to failure of a food stimulus to reach the intestine, because Vgx-C and Sham rats emptied equivalent volumes of liquid food from the stomach into the intestine within 10 min of food entering the stomach. These results indicate that the abdominal vagus is an important neurological substrate for food-related drinking in the rat.
F S Kraly; G P Smith; W J Carty
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of comparative and physiological psychology     Volume:  92     ISSN:  0021-9940     ISO Abbreviation:  J Comp Physiol Psychol     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-09-15     Completed Date:  1978-09-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0414612     Medline TA:  J Comp Physiol Psychol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  196-203     Citation Subset:  IM    
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MeSH Terms
Drinking Behavior / physiology*
Feeding Behavior / physiology*
Food Deprivation
Functional Laterality
Osmolar Concentration
Reaction Time
Solutions / metabolism
Vagus Nerve / physiology*
Reg. No./Substance:

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