| Abdominal sensitivity in the first year of life: comparison of infants with and without prenatally diagnosed unilateral hydronephrosis. | |
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MedLine Citation:
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PMID: 12435457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There are few studies on visceral pain in infants, despite its clinical importance. We have used the abdominal skin reflex (ASR) to measure changes in abdominal sensitivity in the presence of visceral pathology in infants. The reflex was elicited by applying calibrated von Frey hairs to each side of the abdomen and the mechanical threshold and the degree of reflex radiation as denoted by hip flexion were measured. The developmental progression of ASR properties during the first year of life was studied in a cross-sectional sample of healthy infants ranging from 30 to 95 weeks postconceptional age (PCA). These properties were compared to those in infants with unilateral hydronephrosis (UH) using a blinded protocol. Infants with UH were studied at their first outpatient appointment after birth, and postoperatively following surgery if this was indicated. The investigators were blinded to laterality and severity of hydronephrosis until data were analysed, or until surgery. A total of 30 patients with UH and 77 healthy infants were included in the study. In 21 (70%) patients, the side of hydronephrosis had a significantly lower ASR threshold than the contralateral side of the abdomen. There was a significant increase in reflex threshold and decrease in reflex radiation with increasing PCA in control infants. However, in UH infants, this relationship did not exist, even on the unaffected side of the abdomen.Our results show that infants with prenatally diagnosed UH demonstrate increased abdominal sensitivity compared with control infants. Using the ASR, we have provided the first evidence of referred visceral hypersensitivity in infants. |
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Authors:
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K A Andrews; D Desai; H K Dhillon; D T Wilcox; M Fitzgerald |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pain Volume: 100 ISSN: 0304-3959 ISO Abbreviation: Pain Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-11-18 Completed Date: 2003-03-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7508686 Medline TA: Pain Country: Netherlands |
Other Details:
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Languages: eng Pagination: 35-46 Citation Subset: IM |
Affiliation:
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Children Nationwide Paediatric Pain Research Centre, Department of Anatomy, University College London, Gower Street, London WC1E 6BT, UK. k.andrews@ich.ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abdomen Cross-Sectional Studies Hip Joint Humans Hydronephrosis / diagnosis*, surgery Infant Kidney Pelvis Movement Muscle Contraction Pain Measurement / methods* Pain Threshold* Prenatal Diagnosis* Reflex Skin |
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