Document Detail


Abdominal segment reduction: development and evolution of a deeply fixed trait.
MedLine Citation:
PMID:  23026836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
When a new student first begins to push flies, an immediate skill that must be learned is sorting the sexes. In Drosophila melanogaster several sexually dimorphic characters can be used to readily distinguish males from females including abdominal pigmentation, male sex combs and genital morphology. Another, often-overlooked, sexual dimorphism is adult abdominal segment number. Externally, adult Drosophila males possess one fewer abdominal segment than females; the terminal pre-genital segment apparently either absent or fused with the next-most anterior segment. Beyond known roles for the homeotic protein Abdominal-B (Abd-B) and the sex-determining transcription factor Doublesex (Dsx) as key regulators of this trait, surprisingly little is known about either the morphogenetic processes or the downstream genetics responsible for patterning these events. We have explored both and found that rapid epithelial reorganization during pupation eliminates a nascent terminal male segment. We found this Abd-B-dependent process results from sex- and segment-specific regulation of diverse developmental targets including the wingless gene and surprisingly, dsx itself. ( 1) (,) ( 2) Here, I review our observations and discuss this trait as a model to explore both dynamics of epithelial morphogenesis as well as the evolution of developmental mechanisms.
Authors:
John H Yoder
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-10-01
Journal Detail:
Title:  Fly     Volume:  6     ISSN:  1933-6942     ISO Abbreviation:  Fly (Austin)     Publication Date:    2012 Oct-Dec
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-06-21     Revised Date:  2013-10-09    
Medline Journal Info:
Nlm Unique ID:  101470897     Medline TA:  Fly (Austin)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  240-5     Citation Subset:  IM    
Affiliation:
Department of Biological Sciences, The University of Alabama, Tuscaloosa, AL, USA. jhyoder@as.ua.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning / genetics*
Body Size
Cell Differentiation
DNA-Binding Proteins / genetics,  metabolism,  physiology
Drosophila Proteins / genetics,  metabolism,  physiology
Drosophila melanogaster / anatomy & histology,  genetics,  growth & development*
Female
Homeodomain Proteins / genetics,  metabolism,  physiology
Male
Models, Biological
Morphogenesis / genetics
Sex Characteristics
Chemical
Reg. No./Substance:
0/Abd-B proteins, Drosophila; 0/DNA-Binding Proteins; 0/DSX protein, Drosophila; 0/Drosophila Proteins; 0/Homeodomain Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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