Document Detail

Abdominal cramp as an adverse effect of travoprost.
MedLine Citation:
PMID:  15652856     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To describe the adverse effect of abdominal cramp caused by travoprost ophthalmic solution in a glaucoma patient. DESIGN: Case report. METHODS: A 34-year-old woman reported abdominal cramp on topical application of travoprost ophthalmic solution. Satisfactory dechallenge and rechallenge procedures were performed. RESULTS: Abdominal cramp occurred approximately 30 minutes after topical application of travoprost on 3 consecutive days. No abdominal cramp developed after substitution of travoprost with latanoprost or normal saline (in the Travatan bottle). Abdominal cramps recurred on rechallenging with travoprost, either in the original Travatan bottle, a latanoprost bottle, or in a Rescula bottle. CONCLUSIONS: Flu-like symptoms (abdominal cramps, malaise and URI) were reported in 4% of patients participating in clinical trials of travoprost but seldom reported postmarketing. Based on the findings of dechallenge and rechallenge procedures, abdominal cramp should be considered a certain adverse effect of travoprost according to the WHO classification.
Yuan-Chieh Lee
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  139     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-17     Completed Date:  2005-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  202-3     Citation Subset:  AIM; IM    
Department of Ophthalmology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
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MeSH Terms
Antihypertensive Agents / adverse effects*
Cloprostenol / adverse effects*,  analogs & derivatives*
Colic / chemically induced*
Glaucoma, Open-Angle / drug therapy
Intraocular Pressure / drug effects
Ophthalmic Solutions
Reg. No./Substance:
0/Antihypertensive Agents; 0/Ophthalmic Solutions; 157283-68-6/travoprost; 40665-92-7/Cloprostenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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