Document Detail

Abdominal aortic healing associated with a thin-walled Dacron-covered endovascular graft in a canine model.
MedLine Citation:
PMID:  12096948     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To characterize the healing response associated with an experimental endovascular graft (EVG) by examining the lumen of the prosthesis and the native vessel wall responses after implantation in a canine model. METHODS: An endovascular graft (EVG) constructed of hookless self-expanding nitinol springs covered by an ultrathin Dacron fabric was placed in the abdominal aorta of 8 dogs following femoral artery catheterization. After 12 weeks, specimens were subjected to histological and immunocytochemical testing to quantitatively and qualitatively analyze the cellular makeup of the luminal and abluminal tissues. RESULTS: Gross examination revealed a glistening, thrombus-free luminal surface on all prostheses, which was confirmed by scanning electron microscopy. The EVGs were well incorporated into the aortic wall, leaving a concentric, smooth flow surface. Immunocytochemistry verified the presence of von Willebrand factor-positive endothelial cells on the luminal surface and alpha-smooth muscle cell actin-positive smooth muscle and/or fibroblast cells in the subendothelial space. A sparse inflammatory response and a paucity of proliferating nuclear cell antigen-positive cells were noted within the neomedial lining adjacent to the graft material. In addition, a rich vaso vasorum-like plexus of microvessels was evident within the neomedial tissue. The native vessel wall upon which the EVG impinged was largely unaffected. CONCLUSIONS; These data demonstrate that placement of an experimental EVG in the canine abdominal aorta elicits a healing response that is distinct from interpositional vascular grafts. Results from this study have particular relevance to the proximal and distal anastomotic neck regions.
Donny B Dal Ponte; Scott S Berman; Vangie Patula; Leigh Kleinert; Stuart K Williams
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists     Volume:  9     ISSN:  1526-6028     ISO Abbreviation:  J. Endovasc. Ther.     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-07-04     Completed Date:  2002-09-05     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  100896915     Medline TA:  J Endovasc Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  333-43     Citation Subset:  IM    
Biomedical Engineering Program, University of Arizona, 1501 North Campbell Avenue, Tucson, AZ 85724-5084, USA.
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MeSH Terms
Actins / analysis
Aorta, Abdominal / chemistry,  pathology*,  surgery
Blood Vessel Prosthesis
Blood Vessel Prosthesis Implantation*
Coated Materials, Biocompatible
Endothelium, Vascular / chemistry
Fibroblasts / chemistry
Muscle, Smooth, Vascular / chemistry
Neovascularization, Physiologic
Polyethylene Terephthalates*
Proliferating Cell Nuclear Antigen / analysis
Wound Healing*
von Willebrand Factor / analysis
Reg. No./Substance:
0/Actins; 0/Alloys; 0/Coated Materials, Biocompatible; 0/Polyethylene Terephthalates; 0/Proliferating Cell Nuclear Antigen; 0/von Willebrand Factor; 52013-44-2/nitinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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