| Abdominal aortic aneurysms and alpha 1-antitrypsin deficiency. | |
| | |
MedLine Citation:
|
PMID: 7964438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The incidence of abdominal aortic aneurysms (AAAs) has been reported to be increased in heterozygous (PiMZ) and homozygous (PiZZ) alpha 1-antitrypsin (alpha 1 AT) deficiency. We report a further case of AAA in a PiSZ alpha 1AT-deficient female with primary biliary cirrhosis (PBC). Moreover, to assess the risk of AAA in patients with PiZZ alpha 1AT deficiency, we conducted a retrospective study based on 30 consecutive autopsied adult cases of severe alpha 1AT deficiency identified during the period 1963-1993 in the city of Malmö, Sweden, during which autopsies were performed in 49,548, or 58.4%, of all residents in the city who died. From the homozygote frequency in the general population, 50 of these would be expected to have alpha 1AT deficiency. The disease had been diagnosed in 35, and autopsies had been performed in 30 adults. Each autopsied case was matched with four controls selected from the same autopsy register, and the Mantel-Haenszel odds ratio (ORmh) was calculated. We found one case of AAA amongst the 30 PiZZ individuals autopsied, and one case amongst 120 autopsied controls (ORmh = 2.65, 95% confidence limits, 0.47-15.0; P = 0.273). We found no significant evidence of the relationship between AAA and the PiZZ polymorphism, although previously reported by others. At least in severe alpha 1AT deficiency, any coexistence of the PiZZ phenotype and AAA would seem to be fortuitous. |
| | |
Authors:
|
A N Elzouki; S Eriksson |
Related Documents
:
|
8710158 - Experience with zinc protoporphyrin as a marker of endogenous iron availability in chro... 2128938 - Acquired haemophilia. 17301438 - Angioedema in a patient with c1 esterase inhibitor deficiency. 23569788 - A case report of pulmonary coinfection of strongyloides stercoralis and pneumocystis ji... 15983738 - Successful treatment of antifungal- and cryotherapy-resistant subcutaneous hyalohyphomy... 11908828 - Mycoplasmal respiratory infections in small animals: 17 cases (1988-1999). |
Publication Detail:
|
Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of internal medicine Volume: 236 ISSN: 0954-6820 ISO Abbreviation: J. Intern. Med. Publication Date: 1994 Nov |
Date Detail:
|
Created Date: 1994-11-29 Completed Date: 1994-11-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 587-91 Citation Subset: IM |
Affiliation:
|
Department of Medicine, University of Lund, Malmö General Hospital, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aortic Aneurysm, Abdominal / enzymology*, genetics Autopsy Case-Control Studies Female Humans Phenotype alpha 1-Antitrypsin Deficiency* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Quality control in ultrasound studies on atherosclerosis.
Next Document: Chronic idiopathic pure red cell aplasia: successful treatment during pregnancy and durable response...