Document Detail

Abdominal aortic aneurysm and aortic occlusive disease: a comparison of risk factors and inflammatory response.
MedLine Citation:
PMID:  11112466     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: to compare patients with abdominal aortic aneurysm (AAA) and aortic occlusive disease (AOD) with regard to risk factors for atherosclerosis, co-morbid conditions and inflammatory activity. PATIENTS AND METHODS: a total of 155 patients undergoing abdominal aortic surgery between January 1993 and October 1997: 82 (53%) had aneurysmal disease and 73 (47%) had occlusive disease. Principal risk factors were compared: age; gender; smoking; hypertension; hyperlipidaemia; diabetes mellitus; severe peripheral vascular disease (PVD) and ischaemic heart disease. Aortic wall tissue samples were obtained during surgery. A prospective blind analysis was performed for the presence of inflammatory cytokines TNF-alpha, IL-1 beta, IL-6 and TGF-beta. RESULTS: the average age of AAA patients was 74 years (50-88), while that of AOD patients was 61 years (43-82) (p<0.0001). Diabetes mellitus was found to be much more prevalent in the AOD group (p<0.001), while hypertension and severe PVD were more prevalent in the AAA group (p<0.001). No differences were found concerning any of the risk factors. Inflammatory cytokine activity: AAA tissue samples contained significantly higher mean TNF-alpha and IL-6 levels compared to the AOD samples (5.6+/-2.7 x 10 E-4 vs. 4.4+/-2.7 x 10 E-5 atmoles/microl (p=0. 01), and 0.6+/-0.4 vs. 0.01+/-0.006 atmoles/microl (p=0.02) respectively). No differences were found related to IL-1 beta and TGF-beta. CONCLUSIONS: (1) Patients with AAA have fewer atherosclerotic risk factors than do patients with AOD. (2) Patients with AAA and AOD have significantly different inflammatory activity. (3) The data supports the hypothesis that AAA and AOD are probably two different pathological entities.
D Shteinberg; M Halak; S Shapiro; A Kinarty; E Sobol; N Lahat; R Karmeli
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery     Volume:  20     ISSN:  1078-5884     ISO Abbreviation:  Eur J Vasc Endovasc Surg     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2001-02-09     Completed Date:  2001-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9512728     Medline TA:  Eur J Vasc Endovasc Surg     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  462-5     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Harcourt Publishers Ltd.
Vascular Surgery Department, Carmel Medical Center, Haifa, Israel.
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MeSH Terms
Age Factors
Aged, 80 and over
Aortic Aneurysm, Abdominal / etiology*
Aortic Diseases / etiology*
Coronary Disease / complications
Diabetes Complications
Hyperlipidemias / complications
Hypertension / complications
Interleukin-1 / analysis
Interleukin-6 / analysis*
Middle Aged
Polymerase Chain Reaction
Prospective Studies
Risk Factors
Sex Factors
Smoking / adverse effects
Transforming Growth Factor beta / analysis
Tumor Necrosis Factor-alpha / analysis*
Vascular Diseases / complications
Reg. No./Substance:
0/Interleukin-1; 0/Interleukin-6; 0/Transforming Growth Factor beta; 0/Tumor Necrosis Factor-alpha

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