Document Detail

Abdominal aortic aneurysm as an autoimmune disease.
MedLine Citation:
PMID:  11795304     Owner:  NLM     Status:  MEDLINE    
The pathogenesis of abdominal aortic aneurysms (AAAs) is unknown. We hypothesize that the autoimmune disease process plays a key role in the development of AAAs. Both cellular and humoral immunity is involved in the pathogenesis of AAAs. Triggers of autoimmunity are multifactorial. Certain HLA typing is closely related to AAAs, and a certain viral infection may have a potential role in the etiology of AAA via a molecular mimicry mechanism. The autoantigen is located in the microfibrillar compartment of the aortic wall as a normal structure. Patients with AAA are immunoreactive with this novel structural protein. If in the future the autoantigen is fully elucidated, serum testing to detect antibody against the autoantigen can be performed.
H Hirose; M D Tilson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  947     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2002-01-17     Completed Date:  2002-02-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  416-8     Citation Subset:  IM    
Department of Cardiovascular Surgery, Kobari General Hospital, Noda City, Chiba, Japan.
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MeSH Terms
Aortic Aneurysm, Abdominal / blood,  immunology*,  pathology
Autoantibodies / blood*
Autoimmune Diseases / blood*,  immunology,  pathology
Contractile Proteins / immunology*
Extracellular Matrix Proteins / blood,  immunology
Reg. No./Substance:
0/Autoantibodies; 0/Contractile Proteins; 0/Extracellular Matrix Proteins; 0/microfibrillar protein

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