| Abdominal adiposity and hot flashes among midlife women. | |
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MedLine Citation:
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PMID: 18204407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Two competing hypotheses suggest how adiposity may affect menopausal hot flashes. The "thin hypothesis" asserts that aromatization of androgens to estrogens in body fat should be associated with decreased hot flashes. Conversely, thermoregulatory models argue that body fat should be associated with increased hot flashes. The study objective was to examine associations between abdominal adiposity and hot flashes, including the role of reproductive hormones in these associations. DESIGN: The Study of Women's Health Across the Nation Heart Study (2001-2003) is an ancillary study to the Study of Women's Health Across the Nation, a community-based cohort study. Participants were 461 women (35% African American, 65% white) ages 45 to 58 years with an intact uterus and at least one ovary. Measures included a computed tomography scan to assess abdominal adiposity; reported hot flashes over the previous 2 weeks; and a blood sample for measurement of follicle-stimulating hormone, estradiol, and sex hormone-binding globulin-adjusted estradiol (free estradiol index). Associations were evaluated within multivariable logistic and linear regression models. RESULTS: Every 1-SD increase in total (odds ratio [OR]=1.28; 95% CI: 1.06-1.55) and subcutaneous (OR=1.30; 95% CI: 1.07-1.58) abdominal adiposity was associated with increased odds of hot flashes in age- and site-adjusted models. Visceral adiposity was not associated with hot flashes. Associations were not reduced when models included reproductive hormone concentrations. CONCLUSION: Increased abdominal adiposity, particularly subcutaneous adiposity, is associated with increased odds of hot flashes, favoring thermoregulatory models of hot flashes. Body fat may not protect women from hot flashes as once thought. |
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Authors:
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Rebecca C Thurston; MaryFran R Sowers; Kim Sutton-Tyrrell; Susan A Everson-Rose; Tené T Lewis; Daniel Edmundowicz; Karen A Matthews |
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Publication Detail:
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Type: Journal Article; Multicenter Study; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Menopause (New York, N.Y.) Volume: 15 ISSN: 1072-3714 ISO Abbreviation: Menopause Publication Date: 2008 May-Jun |
Date Detail:
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Created Date: 2008-05-13 Completed Date: 2008-10-07 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9433353 Medline TA: Menopause Country: United States |
Other Details:
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Languages: eng Pagination: 429-34 Citation Subset: IM |
Affiliation:
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From the 1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15217, USA. thurstonrc@upmc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity
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physiology* African Americans Cohort Studies Cross-Sectional Studies European Continental Ancestry Group Female Hot Flashes* / etiology, physiopathology Humans Intra-Abdominal Fat / physiopathology* Middle Aged Obesity / complications, physiopathology Odds Ratio Perimenopause / physiology* Postmenopause / physiology* Subcutaneous Fat / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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AG012505/AG/NIA NIH HHS; AG012546/AG/NIA NIH HHS; HL065581/HL/NHLBI NIH HHS; HL065591/HL/NHLBI NIH HHS; K23 AG029216-05/AG/NIA NIH HHS; R01 HL065581-04/HL/NHLBI NIH HHS; R01 HL065591-02/HL/NHLBI NIH HHS; U01 AG012505-16A1/AG/NIA NIH HHS; U01 AG012546-13/AG/NIA NIH HHS |
| Comments/Corrections | |
Comment In:
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Menopause. 2008 Sep-Oct;15(5):1027; author reply 1027-8
[PMID:
18779683
]
Menopause. 2008 May-Jun;15(3):408-9 [PMID: 18340280 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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