| Abdominal ventral hernia repair with current biological prostheses: an experimental large animal model. | |
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MedLine Citation:
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PMID: 21042180 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Biologic prostheses have emerged to address the limitations of synthetic materials for ventral hernia repairs; however, they lack experimental comparative data. Fifteen swine were randomly assigned to 1 of 3 bioprosthetic groups (DermaMatrix, AlloDerm, and Permacol) after creation of a full thickness ventral fascial defect. At 15 weeks, host incorporation, hernia recurrence, adhesion formation, neovascularization, inflammation, and biomechanical properties were assessed. No animals had hernia recurrence or eventration. DermaMatrix and Alloderm implants demonstrated more adhesions, greater inflammatory infiltration, and more longitudinal laxity, but near identical neovascularization and tensile strength to Permacol. We found that porcine acellular dermal products (Permacol) contain following essential properties of an ideal ventral hernia repair material: low inflammation, less elastin and stretch, lower adhesion rates and cost, and more contracture. The addition of lower cost xenogeneic acellular dermal products to the repertoire of available acellular dermal products demonstrates promise, but requires long-term clinical studies to verify advantages and efficacy. |
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Authors:
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Matthew G Stanwix; Arthur J Nam; Helen G Hui-Chou; Jonathan P Ferrari; Harold M Aberman; Michael L Hawes; Kaspar M Keledjian; Luke S Jones; Eduardo D Rodriguez |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of plastic surgery Volume: 66 ISSN: 1536-3708 ISO Abbreviation: Ann Plast Surg Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805336 Medline TA: Ann Plast Surg Country: United States |
Other Details:
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Languages: eng Pagination: 403-9 Citation Subset: IM |
Affiliation:
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From the R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Johns Hopkins School of Medicine, Baltimore, MD. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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